Spontaneous assembly of an organic-inorganic nucleic acid Z-DNA double-helix structure

Kulikov, V., Johnson, N. A.B., Surman, A. J. , Hutin, M., Kelly, S. K. , Hezwani, M., Long, D.-L. , Meyer, G. and Cronin, L. (2017) Spontaneous assembly of an organic-inorganic nucleic acid Z-DNA double-helix structure. Angewandte Chemie (International Edition), 56(4), pp. 1141-1145. (doi:10.1002/anie.201606658) (PMID:27900812) (PMCID:PMC6057607)

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Abstract

Herein, we report a hybrid polyoxometalate organic–inorganic compound, Na2[(HGMP)2Mo5O15]⋅7 H2O (1; where GMP=guanosine monophosphate), which spontaneously assembles into a structure with dimensions that are strikingly similar to those of the naturally occurring left-handed Z-form of DNA. The helical parameters in the crystal structure of the new compound, such as rise per turn and helical twist per dimer, are nearly identical to this DNA conformation, allowing a close comparison of the two structures. Solution circular dichroism studies show that compound 1 also forms extended secondary structures in solution. Gel electrophoresis studies demonstrate the formation of non-covalent adducts with natural plasmids. Thus we show a route by which simple hybrid inorganic–organic monomers, such as compound 1, can spontaneously assemble into a double helix without the need for a covalently connected linear sequence of nucleic acid base pairs.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Hezwani, Dr Mohammed and Kulikov, Dr Vladislav and Hutin, Dr Marie and Long, Dr De Liang and Johnson, Ms Naomi and Kelly, Dr Sharon and Cronin, Professor Leroy and Surman, Dr Andrew
Authors: Kulikov, V., Johnson, N. A.B., Surman, A. J., Hutin, M., Kelly, S. K., Hezwani, M., Long, D.-L., Meyer, G., and Cronin, L.
College/School:College of Medical Veterinary and Life Sciences > Institute of Molecular Cell and Systems Biology
College of Science and Engineering > School of Chemistry
Journal Name:Angewandte Chemie (International Edition)
Publisher:Wiley - V C H Verlag GmbH & Co. KGaA
ISSN:1433-7851
ISSN (Online):1521-3773
Published Online:30 November 2016
Copyright Holders:Copyright © 2018 The Authors
First Published:First published in Angewandte Chemie (International ed. in English) 56(4):1141-1145
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
577391Programmable Molecular Metal Oxides (PMMOs) - From Fundamentals to ApplicationLeroy CroninEngineering & Physical Sciences Research Council (EPSRC)EP/J015156/1CHEM - CHEMISTRY
646611Programmable 'Digital' Synthesis for Discovery and Scale-up of Molecules, Clusters and NanomaterialsLeroy CroninEngineering & Physical Sciences Research Council (EPSRC)EP/L023652/1CHEM - CHEMISTRY
562821Innovative Manufacturing Research Centre for Continuous Manufacturing and Crystallisation (CMAC)Leroy CroninEngineering & Physical Sciences Research Council (EPSRC)EP/I033459/1CHEM - CHEMISTRY
616021Energy and the Physical Sciences: Hydrogen Production using a Proton Electron BufferLeroy CroninEngineering & Physical Sciences Research Council (EPSRC)EP/K023004/1CHEM - CHEMISTRY
599451Microscale Chemically Reactive Electronic AgentsLeroy CroninEuropean Commission (EC)FP7 ICT MICRE318671CHEM - CHEMISTRY
685741SMARTPOM: Artificial-Intelligence Driven Discovery and Synthesis of Polyoxometalate ClustersLeroy CroninEuropean Research Council (ERC)670467CHEM - CHEMISTRY