Monitoring of dynamin during the Toxoplasma gondii cell cycle

Caldas, L. A., Lemgruber Soares, L. , Seabra, S. H., Attias, M. and de Souza, W. (2016) Monitoring of dynamin during the Toxoplasma gondii cell cycle. Pathogens and Disease, 74(9), ftw108. (doi: 10.1093/femspd/ftw108) (PMID:27811048)

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The obligate intracellular protozoan parasite Toxoplasma gondii actively invades virtually all warm-blooded nucleated cells. This process results in a non-fusogenic vacuole, inside which the parasites replicate continuously until egress signaling is triggered. In this work, we investigated the role of the large GTPase dynamin in the interaction of T. gondii with the host cell by using laser and electron microscopy during three key stages: invasion, development and egress. The detection of dynamin during invasion indicates the occurrence of endocytosis, while T. gondii egress appeared to be independent of dynamin participation. However, the presence of dynamin during T. gondii development suggests that this molecule plays undescribed roles in the tachyzoite's cell cycle.

Item Type:Articles
Additional Information:This work was supported by grants from Conselho Nacional de Desenvolvimento Cient´ıfico e Tecnologico CNPq; Financiadora de Estudos e Projetos – FINEP and Fundac¸ao Carlos Chagas Filho ˜ de Apoio a Pesquisa do Rio de Janeiro – FAPERJ to the authors. ` Lucio Ayres Caldas and Leandro Lemgruber Soares received fellowships from Pronametro- Inmetro.
Glasgow Author(s) Enlighten ID:Lemgruber Soares, Dr Leandro
Authors: Caldas, L. A., Lemgruber Soares, L., Seabra, S. H., Attias, M., and de Souza, W.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Pathogens and Disease
Journal Abbr.:Pathog Dis
Publisher:Oxford University Press
ISSN (Online):2049-632X
Published Online:02 November 2016
Copyright Holders:Copyright © 2016 FEMS
First Published:First published in Pathogens and Disease 74(9):ftw108
Publisher Policy:Reproduced in accordance with the publisher copyright policy

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