Hypoxia activates IKK–NF-κB and the immune response in Drosophila melanogaster

Bandarra, D., Biddlestone, J., Mudie, S., Muller, H. A. and Rocha, S. (2014) Hypoxia activates IKK–NF-κB and the immune response in Drosophila melanogaster. Bioscience Reports, 34(4), pp. 429-440. (doi: 10.1042/BSR20140095) (PMID:24993778) (PMCID:PMC4114064)

Abstract

Hypoxia, or low oxygen availability, is an important physiological and pathological stimulus for multicellular organisms. Molecularly, hypoxia activates a transcriptional programme directed at restoration of oxygen homoeostasis and cellular survival. In mammalian cells, hypoxia not only activates the HIF (hypoxia-inducible factor) family, but also additional transcription factors such as NF-κB (nuclear factor κB). Here we show that hypoxia activates the IKK–NF-κB [IκB (inhibitor of nuclear factor κB)–NF-κB] pathway and the immune response in Drosophila melanogaster. We show that NF-κB activation is required for organism survival in hypoxia. Finally, we identify a role for the tumour suppressor Cyld, as a negative regulator of NF-κB in response to hypoxia in Drosophila. The results indicate that hypoxia activation of the IKK–NF-κB pathway and the immune response is an important and evolutionary conserved response.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Biddlestone, Dr John
• Authors: Bandarra, D., Biddlestone, J., Mudie, S., Muller, H. A., and Rocha, S.
• College/School: College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
• Journal Name: Bioscience Reports
• Publisher: Portland Press
• ISSN: 0144-8463
• ISSN (Online): 1573-4935
• Copyright Holders: Copyright © 2014 The Authors
• First Published: First published in Bioscience Reports 34(4):429-440
• Publisher Policy: Reproduced under a Creative Commons License