Mostafa, M. A.B., Calder, E. D.D., Sutherland, A. and Racys, D. T. (2016) Intermolecular Aryl C-H amination using sequential iron and copper catalysis. Chemistry: A European Journal, 23(5), pp. 1044-1047. (doi: 10.1002/chem.201605671) (PMID:27918637)
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Abstract
A mild, efficient and regioselective method for para-amination of activated arenes has been developed through a combination of iron and copper catalysis. A diverse range of products were obtained from an operationally simple one-pot, two-step procedure involving bromination of the aryl substrate with the powerful Lewis acid iron(III) triflimide, followed by a copper(I)-catalysed N-arylation reaction. This two-step dehydrogenative process for the regioselective coupling of aromatic C−H bonds with non-activated amines was applicable to anisole-, phenol-, aniline- and acetanilide-type aryl compounds. Importantly, the arene substrates were used as the limiting reagent and required no protecting-group manipulations during the transformation.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Calder, Mr Ewen and Racys, Dr Daugirdas and Mostafa, Mohamed and Sutherland, Professor Andrew |
Authors: | Mostafa, M. A.B., Calder, E. D.D., Sutherland, A., and Racys, D. T. |
College/School: | College of Science and Engineering > School of Chemistry College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine |
Journal Name: | Chemistry: A European Journal |
Publisher: | Wiley |
ISSN: | 0947-6539 |
ISSN (Online): | 1521-3765 |
Published Online: | 05 December 2016 |
Copyright Holders: | Copyright © 2017 The Authors |
First Published: | First published in Chemistry: A European Journal 23(5):1044-1047 |
Publisher Policy: | Reproduced under a Creative Commons License |
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