Endothelial glycocalyx layer shedding following lung resection

Arthur, A., McCall, P. , Jolly, L., Kinsella, J., Kirk, A. and Shelley, B. (2016) Endothelial glycocalyx layer shedding following lung resection. Biomarkers in Medicine, 10(10), pp. 1033-1038. (doi:10.2217/bmm-2016-0163) (PMID:27643669)

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Abstract

Aim: We investigated if the serum biomarkers of endothelial glycocalyx layer (EGL) disruption, heparan sulfate proteoglycan (HSPG) and syndecan-1 (SDC1) were elevated following lung resection surgery. Methods: Plasma samples were collected from 16 patients undergoing lobectomy for primary lung cancer. HSPG and SDC1 were measured at five perioperative timepoints. Postoperative oxygenation was recorded. Results: Post-hoc pair wise comparisons showed SDC1 concentration was significantly elevated on postoperative day 2, p < 0.001. There was no relationship found between HSPG or SDC1 levels and postoperative oxygenation. Conclusion: Our pilot study is the first to provide evidence of EGL disruption following lung resection surgery. We hypothesize that EGL disruption is involved in the pathogenesis of post-lung resection acute lung injury.

Item Type:Articles
Additional Information:Abstract presentation: This work was presented in a part at the Anaesthetic Research Society Spring Meeting, Royal College of Anaesthetists, London, UK, 22 April 2015.
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Kirk, Mr Alan and McCall, Dr Philip and Shelley, Dr Benjamin and Kinsella, Professor John and Jolly, Miss Lisa and Arthur, Dr Alexander
Authors: Arthur, A., McCall, P., Jolly, L., Kinsella, J., Kirk, A., and Shelley, B.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
Journal Name:Biomarkers in Medicine
Publisher:Future Medicine Ltd.
ISSN:1752-0363
ISSN (Online):1752-0371

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