De novo protein design: how do we expand into the universe of possible protein structures?

Woolfson, D. N., Bartlett, G. J., Burton, A. J., Heal, J. W., Niitsu, A., Thomson, A. R. and Wood, C. W. (2015) De novo protein design: how do we expand into the universe of possible protein structures? Current Opinion in Structural Biology, 33, pp. 16-26. (doi:10.1016/j.sbi.2015.05.009) (PMID:26093060)

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Abstract

Protein scientists are paving the way to a new phase in protein design and engineering. Approaches and methods are being developed that could allow the design of proteins beyond the confines of natural protein structures. This possibility of designing entirely new proteins opens new questions: What do we build? How do we build into protein-structure space where there are few, if any, natural structures to guide us? To what uses can the resulting proteins be put? And, what, if anything, does this pursuit tell us about how natural proteins fold, function and evolve? We describe the origins of this emerging area of fully de novo protein design, how it could be developed, where it might lead, and what challenges lie ahead.

Item Type:Articles
Additional Information:The authors were supported by grants from the BBSRC (BB/ J008990/1) and the ERC (340764) to DNW. AJB and CWW are supported by the EPSRC Bristol Chemical Synthesis Centre for Doctoral Training and the BBSRC South West Doctoral Training Partnership, respectively.
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Thomson, Dr Drew
Authors: Woolfson, D. N., Bartlett, G. J., Burton, A. J., Heal, J. W., Niitsu, A., Thomson, A. R., and Wood, C. W.
College/School:College of Science and Engineering > School of Chemistry
Journal Name:Current Opinion in Structural Biology
Publisher:Elsevier
ISSN:0959-440X
Published Online:18 June 2015
Copyright Holders:Copyright © 2015 The Authors
First Published:First published in Current Opinion in Structural Biology 33: 16-26
Publisher Policy:Reproduced under a Creative Commons License

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