Bromley, E. H.C., Sessions, R. B., Thomson, A. R. and Woolfson, D. N. (2009) Designed α-helical tectons for constructing multicomponent synthetic biological systems. Journal of the American Chemical Society, 131(3), pp. 928-930. (doi: 10.1021/ja804231a) (PMID:19115943)
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Abstract
One possible route to develop new synthetic-biological systems is to assemble discrete nanoscale objects from programmed peptide-based building blocks. We describe an algorithm to design such blocks based on the coiled-coil protein-folding motif. The success of the algorithm is demonstrated by the production of six peptides that form three target parallel, blunted-ended heterodimers in preference to any of the other promiscuous pairings and alternate configurations, for example, homodimers, sticky-ended assemblies, and antiparallel arrangements. The peptides were linked to promote the assembly of larger, defined nanoscale rods, thus demonstrating that targeted peptide−peptide interactions can be specified in complex mixtures.
| Item Type: | Articles |
|---|---|
| Additional Information: | The authors thank the EPSRC (GR/T09224/01) and HFSP (RPG31/2007) for funding. |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Thomson, Dr Drew |
| Authors: | Bromley, E. H.C., Sessions, R. B., Thomson, A. R., and Woolfson, D. N. |
| College/School: | College of Science and Engineering > School of Chemistry |
| Journal Name: | Journal of the American Chemical Society |
| Publisher: | American Chemical Society |
| ISSN: | 0002-7863 |
| ISSN (Online): | 1520-5126 |
| Published Online: | 30 December 2008 |
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