HPV status and favorable outcome in vulvar squamous cancer

Wakeham, K., Kavanagh, K., Cuschieri, K., Millan, D., Pollock, K. G., Bell, S., Burton, K., Reed, N. S. and Graham, S. V. (2017) HPV status and favorable outcome in vulvar squamous cancer. International Journal of Cancer, 140(5), pp. 1134-1146. (doi:10.1002/ijc.30523) (PMID:27864932)

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Abstract

It is universally accepted that high-risk human papillomavirus (HR-HPV) is the cause of cervical dysplasia and cancer. More recently, it has been shown that HPV is also a marker of clinical outcome in oropharyngeal cancer. However, contemporary information is lacking on both the prevalence of HPV infection in vulvar cancer (VSCC), its precursor lesion, vulvar intraepithelial neoplasia (VIN) and the influence of HPV-status on the prognosis of this malignancy. We have conducted a detailed population-based study to examine rates of progression of VIN to VSCC, type-specific HPV prevalence in vulvar disease and the influence of HPV status on clinical outcome in VSCC. We observed that the age at which women are diagnosed with VSCC is falling and there is a significant time gap between first diagnosis of VIN and progression to invasive disease. HR-HPV infection was detected in 87% (97/112) cases of VIN and 52% cases (32/62) of VSCC. The presence of HR-HPV in squamous intraepithelial lesion was associated with lower rates of progression to invasive cancer (hazard ratio, 0.22, p = 0.001). In the adjusted analysis, HR-HPV was associated with improved progression-free survival of VSCC compared to those with HPV negative tumours (hazard ratio, 0.32, p = 0.02).

Item Type:Articles
Additional Information:We would like to thank The Beatson Oncology Centre Fund for supporting this study.
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Graham, Professor Sheila and Wakeham, Dr Katie
Authors: Wakeham, K., Kavanagh, K., Cuschieri, K., Millan, D., Pollock, K. G., Bell, S., Burton, K., Reed, N. S., and Graham, S. V.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:International Journal of Cancer
Publisher:Wiley
ISSN:0020-7136
ISSN (Online):1097-0215
Published Online:16 November 2016
Copyright Holders:Copyright © 2016 UICC
First Published:First published in International Journal of Cancer 140(5): 1134-1146
Publisher Policy:Reproduced in accordance with the publisher copyright policy

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