Prediction and prevention of parasitic diseases using a landscape genomics framework

Schwabl, P., Llewellyn, M. S. , Landguth, E. L., Andersson, B., Kitron, U., Costales, J. A., Ocaña, S. and Grijalva, M. J. (2017) Prediction and prevention of parasitic diseases using a landscape genomics framework. Trends in Parasitology, 33(4), pp. 264-275. (doi:10.1016/j.pt.2016.10.008) (PMID:27863902)

Schwabl, P., Llewellyn, M. S. , Landguth, E. L., Andersson, B., Kitron, U., Costales, J. A., Ocaña, S. and Grijalva, M. J. (2017) Prediction and prevention of parasitic diseases using a landscape genomics framework. Trends in Parasitology, 33(4), pp. 264-275. (doi:10.1016/j.pt.2016.10.008) (PMID:27863902)

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Abstract

Substantial heterogeneity exists in the dispersal, distribution and transmission of parasitic species. Understanding and predicting how such features are governed by the ecological variation of landscape they inhabit is the central goal of spatial epidemiology. Genetic data can further inform functional connectivity among parasite, host and vector populations in a landscape. Gene flow correlates with the spread of epidemiologically relevant phenotypes among parasite and vector populations (e.g., virulence, drug and pesticide resistance), as well as invasion and re-invasion risk where parasite transmission is absent due to current or past intervention measures. However, the formal integration of spatial and genetic data (‘landscape genetics’) is scarcely ever applied to parasites. Here, we discuss the specific challenges and practical prospects for the use of landscape genetics and genomics to understand the biology and control of parasitic disease and present a practical framework for doing so.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Llewellyn, Dr Martin
Authors: Schwabl, P., Llewellyn, M. S., Landguth, E. L., Andersson, B., Kitron, U., Costales, J. A., Ocaña, S., and Grijalva, M. J.
College/School:College of Medical Veterinary and Life Sciences > Institute of Biodiversity Animal Health and Comparative Medicine
College of Medical Veterinary and Life Sciences > School of Life Sciences
Journal Name:Trends in Parasitology
Publisher:Elsevier (Cell Press)
ISSN:1471-4922
ISSN (Online):1471-5007
Published Online:16 November 2016

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