Aspergillus biofilms in human disease

Williams, C., Rajendran, R. and Ramage, G. (2016) Aspergillus biofilms in human disease. In: Imbert, C. (ed.) Fungal Biofilms and Related Infections: Advances in Microbiology, Infectious Diseases and Public Health Volume 3. Series: Advances in Experimental Medicine and Biology, 931 (931). Springer International Publishing, pp. 1-11. ISBN 9783319423593 (doi:10.1007/5584_2016_4)

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The biofilm phenotype of Aspergillus species is an important and accepted clinical entity. While industrially these biofilms have been used extensively in important biofermentations, their role in clinical infection is less well defined. A recent flurry of activity has demonstrated that these interesting filamentous moulds have the capacity to form biofilms both in vitro and in vivo, and through various investigations have shown that these are exquisitely resistant to antifungal therapies through a range of adaptive resistance mechanisms independent of defined genetic changes. This review will explore the clinical importance of these biofilms and provide contemporary information with respect to their clinical management.

Item Type:Book Sections
Glasgow Author(s) Enlighten ID:Ramage, Professor Gordon and Rajendran, Dr Ranjith
Authors: Williams, C., Rajendran, R., and Ramage, G.
College/School:College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing > Dental School
Publisher:Springer International Publishing
Published Online:07 June 2016

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