Bassendine, M.F., Nielsen, S.U., Bridge, S.H., Felmlee, D.J., Sheridan, D.A., Packard, C.J. and Neely, R.D. (2017) Hepatitis C virus and atherosclerosis: a legacy after virologic cure? Clinics and Research in Hepatology and Gastroenterology, 41(1), pp. 25-30. (doi: 10.1016/j.clinre.2016.09.008) (PMID:27840032)
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Abstract
Hepatitis C virus (HCV) is a major pathogen with approximately 3% of the world's population (over 170 million) infected. Epidemiological studies have shown HCV is associated with an increased risk of cardiovascular and cerebrovascular mortality as well as peripheral arterial disease. This is despite HCV inducing an ostensibly favourable lipid profile with accompanying low classical risk score for atherosclerosis (AS). We discuss possible factors involved in the aetiopathogenesis of atherosclerosis in chronic HCV and hypothesise that an important mechanism underlying the development of AS is the presence of circulating low-density immune complexes that induce an inflammatory response. We suggest that HCV particles may be inducing an antibody response to lipoproteins present in the lipoviral particles and sub-viral particles – a concept similar to the more general ‘autoantibody’ response to modified LDL. After virologic cure some AS risk factors will recede but an increase in serum cholesterol could result in progression of early atherosclerotic lesions, leaving a legacy from persistent HCV infection that has clinical and therapeutic implications.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Packard, Professor Chris |
| Authors: | Bassendine, M.F., Nielsen, S.U., Bridge, S.H., Felmlee, D.J., Sheridan, D.A., Packard, C.J., and Neely, R.D. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health |
| Journal Name: | Clinics and Research in Hepatology and Gastroenterology |
| Publisher: | Elsevier |
| ISSN: | 2210-7401 |
| ISSN (Online): | 2210-741X |
| Published Online: | 11 November 2016 |
| Copyright Holders: | Copyright © 2016 Elsevier Masson SAS |
| First Published: | First published in Clinics and Research in Hepatology and Gastroenterology 41(1):25-30 |
| Publisher Policy: | Reproduced in accordance with the copyright policy of the publisher |
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