Evaluation of the modified Glasgow Prognostic Score to predict outcome in dogs with newly diagnosed lymphoma

Fontaine, S.J. , Mcculloch, E. , Eckersall, P.D. , Haining, H., Patterson Kane, J.C. and Morris, J.S. (2017) Evaluation of the modified Glasgow Prognostic Score to predict outcome in dogs with newly diagnosed lymphoma. Veterinary and Comparative Oncology, 15(4), pp. 1513-1526. (doi:10.1111/vco.12296) (PMID:28150446)

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Abstract

The modified Glasgow Prognostic Score (mGPS) assigns a numerical value (0–2) from pre-treatment serum concentrations of C-reactive protein (CRP) and albumin to predict patient outcome. CRP and albumin were evaluated in 77 untreated dogs with lymphoma to determine the relationship of mGPS to clinicopathological parameters and whether it could predict progression-free (PFS) and overall survival (OS) in treated dogs. mGPS distribution was significantly associated with clinical stage, substage b, weight loss, gastrointestinal disturbances and lethargy at presentation. On univariate analysis, mGPS was significantly associated with OS and PFS, with shorter median survival times for mGPS 2 compared to mGPS 0 and 1 combined. Hypoalbuminaemia significantly reduced OS and PFS, however increased CRP had no effect. Only clinical stage was significantly associated with OS and PFS on both univariate and multivariate analysis. mGPS has potential prognostic value for canine lymphoma , but further studies are needed.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Eckersall, Professor Peter and Fontaine, Ms Samantha and Morris, Professor Joanna and Haining, Dr Hayley and Mcculloch, Miss Eilidh
Authors: Fontaine, S.J., Mcculloch, E., Eckersall, P.D., Haining, H., Patterson Kane, J.C., and Morris, J.S.
College/School:College of Medical Veterinary and Life Sciences > Institute of Biodiversity Animal Health and Comparative Medicine
College of Medical Veterinary and Life Sciences > School of Veterinary Medicine
Journal Name:Veterinary and Comparative Oncology
Publisher:Wiley
ISSN:1476-5810
ISSN (Online):1476-5829
Published Online:02 February 2017
Copyright Holders:Copyright © 2017 John Wiley and Sons Ltd
First Published:First published in Veterinary and Comparative Oncology 15(4): 1513-1526
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

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