Patterns of activity in the human frontal and parietal cortex differentiate large and small saccades

Grosbras, M.-H. (2016) Patterns of activity in the human frontal and parietal cortex differentiate large and small saccades. Frontiers in Integrative Neuroscience, 10, 34. (doi: 10.3389/fnint.2016.00034) (PMID:27833536) (PMCID:PMC5081348)

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Abstract

A vast literature indicates that small and large saccades, respectively, subserve different perceptual and cognitive strategies and may rely on different programming modes. While it is well-established that in monkeys’ main oculomotor brain regions small and large eye movements are controlled by segregated neuronal populations, the representation of saccade amplitude in the human brain remains unclear. To address this question we used functional magnetic resonance imaging to scan participants while they performed saccades toward targets at either short (4°) or large (30°) eccentricity. A regional multivoxel pattern analysis reveals that patterns of activity in the frontal eye-field and parietal eye fields discriminate between the execution of large or small saccades. This was not the case in the supplementary eye-fields nor in the inferior precentral cortex. These findings provide the first evidence of a representation of saccadic eye movement size in the fronto-parietal occulomotor circuit. They shed light on the respective roles of the different cortical oculomotor regions with respect to space perception and exploration, as well as on the homology of eye movement control between human and non-human primates.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Grosbras, Dr Marie-Helene
Authors: Grosbras, M.-H.
College/School:College of Medical Veterinary and Life Sciences > Institute of Neuroscience and Psychology
Journal Name:Frontiers in Integrative Neuroscience
Publisher:Frontiers Media
ISSN:1662-5145
ISSN (Online):1662-5145
Copyright Holders:Copyright © 2016 The Author
First Published:First published in Frontiers in Integrative Neuroscience 10:34
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
429501Top down control of visual processing and awareness - studies with transcranial magnetic stimulation and electroencephalographyMarie-Helene GrosbrasBiotechnology and Biological Sciences Research Council (BBSRC)BB/E003699/1INP - CENTRE FOR COGNITIVE NEUROIMAGING