Control of human papillomavirus gene expression by alternative splicing

Graham, S. and Faizo, A. A. A. (2017) Control of human papillomavirus gene expression by alternative splicing. Virus Research, 231, pp. 83-95. (doi: 10.1016/j.virusres.2016.11.016) (PMID:27867028) (PMCID:PMC5335905)

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Human papillomaviruses possess circular double stranded DNA genomes of around 8 kb in size from which multiple mRNAs are synthesized during an infectious life cycle. Although at least three viral promoters are used to initiate transcription, viral mRNAs are largely the product of processing of pre-mRNAs by alternative splicing and polyadenylation. The HPV life cycle and viral gene expression are tightly linked to differentiation of the epithelium the virus infects: there is an orchestrated production of viral mRNAs and proteins. In this review we describe viral mRNA expression and the roles of the SR and hnRNP proteins that respectively positively and negatively regulate splicing. We discuss HPV regulation of splicing factors and detail the evidence that the papillomavirus E2 protein has splicing-related activities. We highlight the possibility that HPV-mediated control of splicing in differentiating epithelial cells may be necessary to accomplish the viral replication cycle.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Graham, Professor Sheila and Faizo, Arwa Ali A
Authors: Graham, S., and Faizo, A. A. A.
College/School:College of Medical Veterinary and Life Sciences > School of Infection & Immunity
College of Medical Veterinary and Life Sciences > School of Infection & Immunity > Centre for Virus Research
Journal Name:Virus Research
ISSN (Online):1872-7492
Published Online:17 November 2016
Copyright Holders:Copyright © 2016 The Authors
First Published:First published in Virus Research 231: 83-95
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
507841Human papillomavirus E2 regulation of splicing factors: consequences for the virus life cycleSheila GrahamWellcome Trust (WELLCOME)088848/Z/09/ZMVLS III - CENTRE FOR VIRUS RESEARCH