An international invasive meningococcal disease outbreak due to a novel and rapidly expanding serogroup W strain, Scotland and Sweden, July to August 2015

Lucidarme, J. et al. (2016) An international invasive meningococcal disease outbreak due to a novel and rapidly expanding serogroup W strain, Scotland and Sweden, July to August 2015. Eurosurveillance, 21(45), 30395. (doi: 10.2807/1560-7917.ES.2016.21.45.30395)

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Abstract

The 23rd World Scout Jamboree in 2015 took place in Japan and included over 33,000 scouts from 162 countries. Within nine days of the meeting ending, six cases of laboratory-confirmed invasive serogroup W meningococcal disease occurred among scouts and their close contacts in Scotland and Sweden. The isolates responsible were identical to one-another by routine typing and, where known (4 isolates), belonged to the ST-11 clonal complex (cc11) which is associated with large outbreaks and high case fatality rates. Recent studies have demonstrated the need for high-resolution genomic typing schemes to assign serogroup W cc11 isolates to several distinct strains circulating globally over the past two decades. Here we used such schemes to confirm that the Jamboree-associated cases constituted a genuine outbreak and that this was due to a novel and rapidly expanding strain descended from the strain that has recently expanded in South America and the United Kingdom. We also identify the genetic differences that define the novel strain including four point mutations and three putative recombination events involving the horizontal exchange of 17, six and two genes, respectively. Noteworthy outcomes of these changes were antigenic shifts and the disruption of a transcriptional regulator.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:McMenamin, Dr Jim and Smith, Professor Andrew
Authors: Lucidarme, J., Scott, K.L., Ure, R., Smith, A., Lindsay, D., Stenmark, B., Jacobsson, S., Fredlund, H., Cameron, J.C., Smith-Palmer, A., McMenamin, J., Gray, S.J., Campbell, H., Ladhani, S., Findlow, J., Mölling, P., and Borrow, R.
College/School:College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing > Dental School
Journal Name:Eurosurveillance
Publisher:European Centre for Disease Prevention and Control
ISSN:1560-7917
ISSN (Online):1025-496X
Copyright Holders:Copyright © 2016 The Authors
First Published:First published in Eurosurveillance 21(45):30395
Publisher Policy:Reproduced under a Creative Commons License

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