Gene delivery to cardiovascular tissue

Masson, R., Nicklin, S. A. and Baker, A. H. (2009) Gene delivery to cardiovascular tissue. In: Abraham, D., Handler, C., Dashwood, M. and Coghlan, G. (eds.) Advances in Vascular Medicine. Springer London, pp. 25-54. ISBN 9781848826366 (doi: 10.1007/978-1-84882-637-3_2)

Abstract

A major hurdle in the development of cardiovascular gene therapy is the limited availability of vectors that are tissue- or cell-selective and the need for sufficient longevity of transgene expression in vivo. Nonviral vectors tend to be limited by their low transfection efficiencies and transient gene expression. Viral vectors are more promising, as they can mediate higher levels of transgene expression and are being developed to be more selective for their target organ or cell type. Strategies to improve targeting and reduce immunogenicity have been applied to adenovirus and adeno-associated viral vectors for applications in cardiovascular gene therapy. The discovery of alternate serotypes of adeno-associated virus vectors that have a natural tropism for the myocardium has greatly aided the development of optimal cardiovascular gene delivery.

• Item Type: Book Sections
• Status: Published
• Glasgow Author(s) Enlighten ID: Nicklin, Professor Stuart and Baker, Professor Andrew
• Authors: Masson, R., Nicklin, S. A., and Baker, A. H.
• College/School: College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
• Publisher: Springer London
• ISBN: 9781848826366