Adenoviral vectors

Nicklin, S. A. and Baker, A. H. (2010) Adenoviral vectors. In: Herzog, R. W. and Zolotukhin, S. (eds.) A Guide to Human Gene Therapy. World Scientific Publishing, pp. 21-36. ISBN 9789814280907 (doi: 10.1142/9789814280914_0002)

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Adenoviruses are one of the most widely investigated vectors for gene therapy. Their attributes include ease of genetic manipulation to produce replication-deficient vectors, ability to readily generate high titer stocks, efficiency of gene delivery into many cell types and ability to encode large genetic inserts. Adenoviruses have been utilized for a variety of therapeutic applications particularly for high level transient overexpression in cancer gene therapy, vaccine delivery and certain cardiovascular diseases. With the first licensing of clinical adenoviral gene therapy for cancer treatment the use of adenoviruses is likely to expand in the future. This chapter focuses on the history of adenovirus development, interactions with the host both for gene delivery and immunogenicity as well as potential therapeutic applications.

Item Type:Book Sections
Glasgow Author(s) Enlighten ID:Nicklin, Professor Stuart and Baker, Professor Andrew
Authors: Nicklin, S. A., and Baker, A. H.
College/School:College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
Publisher:World Scientific Publishing

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