Genome-wide analyses for personality traits identify six genomic loci and show correlations with psychiatric disorders

Lo, M.-T. et al. (2016) Genome-wide analyses for personality traits identify six genomic loci and show correlations with psychiatric disorders. Nature Genetics, 49(1), pp. 152-156. (doi:10.1038/ng.3736) (PMID:27918536)

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Abstract

Personality is influenced by genetic and environmental factors1 and associated with mental health. However, the underlying genetic determinants are largely unknown. We identified six genetic loci, including five novel loci2,3, significantly associated with personality traits in a meta-analysis of genome-wide association studies (N = 123,132–260,861). Of these genomewide significant loci, extraversion was associated with variants in WSCD2 and near PCDH15, and neuroticism with variants on chromosome 8p23.1 and in L3MBTL2. We performed a principal component analysis to extract major dimensions underlying genetic variations among five personality traits and six psychiatric disorders (N = 5,422–18,759). The first genetic dimension separated personality traits and psychiatric disorders, except that neuroticism and openness to experience were clustered with the disorders. High genetic correlations were found between extraversion and attention-deficit– hyperactivity disorder (ADHD) and between openness and schizophrenia and bipolar disorder. The second genetic dimension was closely aligned with extraversion–introversion and grouped neuroticism with internalizing psychopathology (e.g., depression or anxiety).

Item Type:Articles (Letter)
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Smith, Professor Daniel
Authors: Lo, M.-T., Hinds, D. A., Tung, J. Y., Franz, C., Fan, C.-C., Wang, Y., Smeland, O. B., Schork, A., Holland, D., Kauppi, K., Sanyal, N., Escott-Price, V., Smith, D. J., O'Donovan, M., Stefansson, H., Bjornsdottir, G., Thorgeirsson, T. E., Stefansson, K., McEvoy, L. K., Dale, A. M., Andreassen, O. A., and Chen, C.-H.
College/School:College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > Mental Health and Wellbeing
Journal Name:Nature Genetics
Publisher:Nature Publishing Group
ISSN:1061-4036
ISSN (Online):1546-1718
Published Online:05 December 2016
Copyright Holders:Copyright © 2016 Nature Publishing Group
First Published:First published in Nature Genetics 49(1):152-156
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

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