Aillard, B., Robertson, N. S., Baldwin, A. R., Robins, S. and Jamieson, A. G. (2014) Robust asymmetric synthesis of unnatural alkenyl amino acids for conformationally constrained α-helix peptides. Organic and Biomolecular Chemistry, 12(43), pp. 8775-8782. (doi: 10.1039/C4OB01832J) (PMID:25266495)
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Abstract
The efficient asymmetric synthesis of unnatural alkenyl amino acids required for peptide ‘stapling’ has been achieved using alkylation of a fluorine-modified NiII Schiff base complex as the key step.
| Item Type: | Articles |
|---|---|
| Additional Information: | This work was funded by Engineering and Physical Sciences Research Council (EPSRC) (EP/L018152/1), University of Leicester Innovation Fellowship for A.G.J. |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Jamieson, Professor Andrew |
| Authors: | Aillard, B., Robertson, N. S., Baldwin, A. R., Robins, S., and Jamieson, A. G. |
| College/School: | College of Science and Engineering > School of Chemistry |
| Journal Name: | Organic and Biomolecular Chemistry |
| Publisher: | Royal Society of Chemistry |
| ISSN: | 1477-0520 |
| ISSN (Online): | 1477-0539 |
| Published Online: | 16 September 2014 |
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