Cunha, A. R., D'El-Rei, J., Medeiros, F., Umbelino, B., Oigman, W., Touyz, R. M. and Neves, M. F. (2017) Oral magnesium supplementation improves endothelial function and attenuates subclinical atherosclerosis in thiazide-treated hypertensive women. Journal of Hypertension, 35(1), pp. 89-97. (doi: 10.1097/HJH.0000000000001129) (PMID:27759579)
|
Text
130809.pdf - Accepted Version 988kB |
Abstract
Background: Epidemiological studies demonstrate an inverse association between serum magnesium and incidence of cardiovascular disease. Diuretics commonly cause hypomagneseamia. Method: We evaluated effects of magnesium supplementation on blood pressure (BP) and vascular function in thiazide-treated hypertensive women in a randomized, double-blind, clinical trial. Hypertensive women (40–65 years) on hydrochlorothiazide and mean 24-h BP at least 130/80 mmHg were divided into placebo and supplementation (magnesium chelate 600 mg/day) groups. Patients were evaluated for nutritional and biochemical parameters, office and ambulatory blood pressure monitoring, brachial flow-mediated dilatation (FMD), peripheral arterial tonometry, assessment of carotid intima–media thickness, central hemodynamic parameters and pulse wave velocity at inclusion and after 6-month follow-up. Results: The magnesium group had a significant reduction in SBP (144 ± 17 vs. 134 ± 14 mmHg, P = 0.036) and DBP (88 ± 9 vs. 81 ± 8 mmHg, P = 0.005) at 6 months, without effect on plasma glucose, lipids, or arterial stiffness parameters. The placebo group showed a significant increase in carotid intima-media thickness (0.78 ± 0.13 vs. 0.89 ± 0.14 mm, P = 0.033) without change in the magnesium group (0.79 ± 0.16 vs. 0.79 ± 0.19 mm, P = 0.716) after 6 months. The magnesium group demonstrated a significant increase in variation of FMD vs. the placebo group (+3.7 ± 2.1 vs. 2.4 ± 1.2%, P = 0.015). There was a significant correlation between the intracellular magnesium variation and FMD (r = 0.44, P = 0.011). Conclusion: Magnesium supplementation was associated with better BP control, improved endothelial function and amelioration of subclinical atherosclerosis in these thiazide-treated hypertensive women.
Item Type: | Articles |
---|---|
Additional Information: | The support was received in grants from Foundation for Research in the State of Rio de Janeiro (FAPERJ). |
Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Touyz, Professor Rhian |
Authors: | Cunha, A. R., D'El-Rei, J., Medeiros, F., Umbelino, B., Oigman, W., Touyz, R. M., and Neves, M. F. |
College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health |
Journal Name: | Journal of Hypertension |
Publisher: | Lippincott Williams & Wilkins |
ISSN: | 0263-6352 |
ISSN (Online): | 1473-5598 |
Copyright Holders: | Copyright © 2016 Wolters Kluwer Health, Inc. |
First Published: | First published in Journal of Hypertension 35(1): 89-97 |
Publisher Policy: | Reproduced in accordance with the publisher copyright policy |
University Staff: Request a correction | Enlighten Editors: Update this record