Using biosensors to study free fatty acid receptor pharmacology and function

Hudson, B. D. (2016) Using biosensors to study free fatty acid receptor pharmacology and function. In: Milligan, G. and Kimura, I. (eds.) Free Fatty Acid Receptors. Series: Handbook of experimental pharmacology (236). Springer, pp. 79-100. ISBN 9783319506920 (doi:10.1007/164_2016_58)

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Abstract

The free fatty acid (FFA) family of G protein coupled receptors (GPCRs) has generated significant interest for exploiting its members as potential drug targets. However, unravelling the complex pharmacology of this family of receptors has proven challenging. In recent years the use of biosensor technologies capable of assessing biological functions in living cells, and in real time, has greatly enhanced our ability to study GPCR pharmacology and function. These include genetically encoded sensors that change the intensity or wavelength of light emitted from a bioluminescent or fluorescent protein in response to a stimulus, as well as non-genetically encoded sensors able to measure more global cellular changes, such as mass redistribution within a cell. This chapter will examine how these sensors can be used to study GPCRs, and in particular how they are helping uncover the pharmacology of the FFA family of receptors.

Item Type:Book Sections
Status:Published
Glasgow Author(s) Enlighten ID:Hudson, Dr Brian
Authors: Hudson, B. D.
College/School:College of Medical Veterinary and Life Sciences > Institute of Molecular Cell and Systems Biology
Journal Name:Handbook of Experimental Pharmacology
Publisher:Springer
ISSN:0171-2004
ISBN:9783319506920
Published Online:19 October 2016

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