T1 hyperintensity on brain imaging subsequent to gadolinium-based contrast agent administration: what do we know about intracranial gadolinium deposition?

Hoggard, N. and Roditi, G. H. (2016) T1 hyperintensity on brain imaging subsequent to gadolinium-based contrast agent administration: what do we know about intracranial gadolinium deposition? British Journal of Radiology, 90(1069), 20160590. (doi: 10.1259/bjr.20160590) (PMID:27653560)

Abstract

There is growing evidence for the accumulation of gadolinium (Gd) in patients administered with intravenous Gd-based contrast agents, even in the absence of renal impairment. This review of the literature will discuss what has been found to date in cadaveric human studies, clinical studies of patients and from animal models. Evidence for the potential route of entry into the brain will be examined. The current state of knowledge of effects of Gd accumulation in the brain is discussed. We will then discuss what the possible implications may be for the choice of Gd-based contrast agents in clinical practice.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Roditi, Dr Giles
• Authors: Hoggard, N., and Roditi, G. H.
• College/School: College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
• Journal Name: British Journal of Radiology
• Publisher: British Institute of Radiolog
• ISSN: 0007-1285
• ISSN (Online): 1748-880X
• Published Online: 19 October 2016
• Copyright Holders: Copyright © 2016 British Institute of Radiology
• First Published: First published in British Journal of Radiology 90(1069):20160590
• Publisher Policy: Reproduced in accordance with the copyright policy of the publisher