Metabolomics

Burgess, K., Rankin, N. and Weidt, S. (2014) Metabolomics. In: Padmanabhan, S. (ed.) Handbook of Pharmacogenomics and Stratified Medicine. Academic Press: London, pp. 181-205. ISBN 9780123868824 (doi:10.1016/B978-0-12-386882-4.00010-4)

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Abstract

Metabolomics is a recently developed technique for the analysis of the small-molecule component of biological systems and samples. Metabolites consist of a very heterogeneous group of organic small molecules, including organic acids, amino acids, sugars, phosphosugars, steroids, and biogenic amines. Because of this diversity, many technologies have been applied to metabolomics. These technologies are based primarily on sensitive spectroscopic and spectrometric methods that are capable of the simultaneous detection and quantitation of metabolites in the hundreds (nuclear magnetic resonance and gas chromatography-mass spectrometry) and thousands (liquid chromatography-mass spectrometry). Metabolite analysis techniques can be split into fingerprinting (diagnostic patterns of disease), profiling (quantitative analysis of large numbers of metabolites), pool analysis (targeted quantitation of a smaller number of metabolites), and flux analysis (tracing metabolite fate and calculation of rates of metabolic processes). They must be subjected to complex data analysis to test or generate hypotheses, followed by contextualization via metabolic pathway analysis. Metabolomics has already become a valuable “omics” technology that complements genomics, transcriptomics, and proteomics.

Item Type:Book Sections
Status:Published
Glasgow Author(s) Enlighten ID:Weidt, Dr Stefan and Rankin, Dr Naomi and Burgess, Dr Karl
Authors: Burgess, K., Rankin, N., and Weidt, S.
College/School:College of Medical Veterinary and Life Sciences
College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Handbook of Pharmacogenomics and Stratified Medicine
Publisher:Academic Press
ISBN:9780123868824

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