Assessment of the construct validity and responsiveness of preference-based quality of life measures in people with Parkinson's: a systematic review

Xin, Y. and McIntosh, E. (2017) Assessment of the construct validity and responsiveness of preference-based quality of life measures in people with Parkinson's: a systematic review. Quality of Life Research, 26(1), pp. 1-23. (doi:10.1007/s11136-016-1428-x) (PMID:27778141)

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Purpose: Generic preference-based quality of life (PbQoL) measures are sometimes criticized for being insensitive or failing to capture important aspects of quality of life (QoL) in specific populations. The objective of this study was to systematically review and assess the construct validity and responsiveness of PbQoL measures in Parkinson’s. Methods: Ten databases were systematically searched up to July 2015. Studies were included if a PbQoL instrument along with a common Parkinson’s clinical or QoL measure was used, and the utility values were reported. The PbQoL instruments were assessed for construct validity (discriminant and convergent validity) and responsiveness. Results: Twenty-three of 2758 studies were included, of which the majority evidence was for EQ-5D. Overall good evidence of discriminant validity was demonstrated in the Health Utility Index (HUI)-3, EQ-5D-5L, EQ-5D-3L, 15D, HUI-2, and Disability and Distress Index (DDI). Nevertheless, HUI-2 and EQ-5D-3L were shown to be less sensitive among patients with mild Parkinson’s. Moderate to strong correlations were shown between the PbQoL measures (EQ-5D-3L, EQ-5D-5L, 15D, DDI, and HUI-II) and Parkinson’s-specific measures. Twelve studies provided evidence for the assessment of responsiveness of EQ-5D-3L and one study for 15D, among which six studies reached inconsistent results between EQ-5D-3L and the Parkinson’s-specific measures in measuring the change overtime. Conclusions: The construct validity of the PbQoL measures was generally good, but there are concerns regarding their responsiveness to change. In Parkinson’s, the inclusion of a Parkinson’s-specific QoL measure or a generic but broader scoped mental and well-being focused measure to incorporate aspects not included in the common PbQoL measures is recommended.

Item Type:Articles
Additional Information:Parkinson's UK award to Oxford F-1001
Glasgow Author(s) Enlighten ID:Xin, Miss Yiqiao and McIntosh, Professor Emma
Authors: Xin, Y., and McIntosh, E.
College/School:College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > Health Economics and Health Technology Assessment
Journal Name:Quality of Life Research
ISSN (Online):1573-2649
Published Online:24 October 2016
Copyright Holders:Copyright © 2016 Springer
First Published:First published in Quality of Life Research 26(1):1-23
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
585181The Economics of Parkinson's Disease: advancing the scope of costs and benefitsEmma McIntoshParkinson's Disease Society (PARKINSONS)UNSPECIFIEDIHW - HEALTH ECON & TECH ASSESSMENT