Association between GDF-15 levels and changes in vascular and physical function in older patients with hypertension

Barma, M., Khan, F., Price, R. J.G., Donnan, P. T., Messow, C. M. , Ford, I. , McConnachie, A. , Struthers, A. D., McMurdo, M. E.T. and Witham, M. D. (2016) Association between GDF-15 levels and changes in vascular and physical function in older patients with hypertension. Aging Clinical and Experimental Research, 29(5), pp. 1055-1059. (doi: 10.1007/s40520-016-0636-0) (PMID:27734214) (PMCID:PMC5589783)

Abstract

Background: Growth differentiation factor-15 (GDF-15) may be a biomarker of disease, protective response and/or prognosis, in older people with hypertension. Aims: To correlate baseline GDF-15 levels with physical and vascular health data in this population. Methods: Baseline blood samples were analysed using a GDF-15 ELISA assay kit. Correlations with baseline and 12-month outcome data, including measures of physical and vascular function, were performed. Results: A total of 147 individuals, mean age 76.8 ± 4.7 years, were included. 77 (52 %) were male. Baseline log10GDF-15 showed significant correlations with age (r = 0.37, p < 0.001), total cholesterol (r = −0.33, p < 0.001) and 6-min walking distance (r = −0.37, p < 0.001). Age remained significantly associated with log10GDF-15 in multivariable analysis (beta = −0.29, p = 0.001). Baseline log10GDF-15 was significantly associated with decline in 6-min walk distance over 12 months (beta = −0.27, p = 0.01) in multivariable models. No significant correlations were seen with changes in vascular function over 12 months. Conclusion: Baseline GDF-15 predicts declining physical, but not vascular, function in our population.

• Item Type: Articles
• Additional Information: The VitDISH trial was funded by Chief Scientist Office, Scottish Government (grant number CZH/4/1100)
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Messow, Dr Martina and McConnachie, Professor Alex and Ford, Professor Ian and Khan, Dr Faisel
• Authors: Barma, M., Khan, F., Price, R. J.G., Donnan, P. T., Messow, C. M., Ford, I., McConnachie, A., Struthers, A. D., McMurdo, M. E.T., and Witham, M. D.
• Subjects: ?? Ageing ??; ?? Biomarker ??; ?? Cardiovascular disease ??; ?? Frailty ??; ?? Inflammation ??
• College/School: College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > Robertson Centre; College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
• Journal Name: Aging Clinical and Experimental Research
• Publisher: Springer Verlag
• ISSN: 1594-0667
• ISSN (Online): 1720-8319
• Published Online: 12 October 2016
• Copyright Holders: Copyright © 2016 The Authors
• First Published: First published in Aging Clinical and Experimental Research 29(5):1055-1059
• Publisher Policy: Reproduced under a Creative Commons License