Association between GDF-15 levels and changes in vascular and physical function in older patients with hypertension

Barma, M., Khan, F., Price, R. J.G., Donnan, P. T., Messow, C. M. , Ford, I. , McConnachie, A. , Struthers, A. D., McMurdo, M. E.T. and Witham, M. D. (2016) Association between GDF-15 levels and changes in vascular and physical function in older patients with hypertension. Aging Clinical and Experimental Research, 29(5), pp. 1055-1059. (doi:10.1007/s40520-016-0636-0) (PMID:27734214) (PMCID:PMC5589783)

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Abstract

Background: Growth differentiation factor-15 (GDF-15) may be a biomarker of disease, protective response and/or prognosis, in older people with hypertension. Aims: To correlate baseline GDF-15 levels with physical and vascular health data in this population. Methods: Baseline blood samples were analysed using a GDF-15 ELISA assay kit. Correlations with baseline and 12-month outcome data, including measures of physical and vascular function, were performed. Results: A total of 147 individuals, mean age 76.8 ± 4.7 years, were included. 77 (52 %) were male. Baseline log10GDF-15 showed significant correlations with age (r = 0.37, p < 0.001), total cholesterol (r = −0.33, p < 0.001) and 6-min walking distance (r = −0.37, p < 0.001). Age remained significantly associated with log10GDF-15 in multivariable analysis (beta = −0.29, p = 0.001). Baseline log10GDF-15 was significantly associated with decline in 6-min walk distance over 12 months (beta = −0.27, p = 0.01) in multivariable models. No significant correlations were seen with changes in vascular function over 12 months. Conclusion: Baseline GDF-15 predicts declining physical, but not vascular, function in our population.

Item Type:Articles
Additional Information:The VitDISH trial was funded by Chief Scientist Office, Scottish Government (grant number CZH/4/1100)
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:McConnachie, Dr Alex and Ford, Professor Ian and Messow, Ms Claudia-Martina and Khan, Dr Faisel
Authors: Barma, M., Khan, F., Price, R. J.G., Donnan, P. T., Messow, C. M., Ford, I., McConnachie, A., Struthers, A. D., McMurdo, M. E.T., and Witham, M. D.
Subjects:?? Ageing ??
?? Biomarker ??
?? Cardiovascular disease ??
?? Frailty ??
?? Inflammation ??
College/School:College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > Robertson Centre
College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
Journal Name:Aging Clinical and Experimental Research
Publisher:Springer Verlag
ISSN:1594-0667
ISSN (Online):1720-8319
Published Online:12 October 2016
Copyright Holders:Copyright © 2016 The Authors
First Published:First published in Aging Clinical and Experimental Research 29(5):1055-1059
Publisher Policy:Reproduced under a Creative Commons License

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