Exposure to secondhand smoke and risk of peripheral arterial disease in southern Chinese non-smokers: the Guangzhou Biobank Cohort Study-Cardiovascular Disease Sub-cohort

Lu, L., Jiang, C., Mackay, D. F. , Pell, J. P. , Cheng, K. K., Lam, T. H. and Thomas, G. N. (2017) Exposure to secondhand smoke and risk of peripheral arterial disease in southern Chinese non-smokers: the Guangzhou Biobank Cohort Study-Cardiovascular Disease Sub-cohort. Vascular, 25(3), pp. 283-289. (doi:10.1177/1708538116673018) (PMID:27770029)

Lu, L., Jiang, C., Mackay, D. F. , Pell, J. P. , Cheng, K. K., Lam, T. H. and Thomas, G. N. (2017) Exposure to secondhand smoke and risk of peripheral arterial disease in southern Chinese non-smokers: the Guangzhou Biobank Cohort Study-Cardiovascular Disease Sub-cohort. Vascular, 25(3), pp. 283-289. (doi:10.1177/1708538116673018) (PMID:27770029)

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Abstract

Objectives: We studied the association between secondhand smoke (SHS) exposure and peripheral arterial disease (PAD) in Chinese non-smokers. Methods: We conducted a cross-sectional study using baseline data from the Guangzhou Biobank Cohort Study: Cardiovascular Disease Sub-cohort Study (GBCS-CVD). Guangzhou residents aged ≥ 50 years were recruited between 2003 and 2008. Baseline data included measurement of ankle brachial pressure index (ABPI) and self-reported smoking status and SHS exposure. Univariate and multivariate logistic regression analyses were used to analyze the association between SHS and PAD (defined as ABPI < 0.9). Results: Of the 1507 non-smokers, 24 (1.6%) had PAD. Of these, 12 were men and 12 were women. Exposure to SHS at home of ≥25 h per week was reported by 16.7% of PAD cases compared with 3.8% of those without PAD (χ2 test, p = 0.003). After adjustment for potential confounders, exposure to ≥25 h per week at home was still associated with PAD (adjusted OR 7.86, 95% CI 2.00–30.95, p = 0.003), with suggestion of a dose-response relationship. Conclusions: Our results extend the US Surgeon General’s 2006 report that SHS exposure is an independent risk factor for PAD. National smoke-free legislation is needed to protect all people from exposure.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Pell, Professor Jill and Mackay, Dr Daniel
Authors: Lu, L., Jiang, C., Mackay, D. F., Pell, J. P., Cheng, K. K., Lam, T. H., and Thomas, G. N.
College/School:College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > Public Health
Journal Name:Vascular
Publisher:SAGE Publications
ISSN:1708-5381
ISSN (Online):1708-539X
Published Online:20 October 2016
Copyright Holders:Copyright © 2016 The Authors
First Published:First published in Vascular 25(3):283-289
Publisher Policy:Reproduced in accordance with the publisher copyright policy

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