Antigen-presenting cells and antigen presentation in tertiary lymphoid organs

Hughes, C. E. , Benson, R. A. , Bedaj, M. and Maffia, P. (2016) Antigen-presenting cells and antigen presentation in tertiary lymphoid organs. Frontiers in Immunology, 7, 481. (doi:10.3389/fimmu.2016.00481) (PMID:27872626) (PMCID:PMC5097899)

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Abstract

Tertiary lymphoid organs (TLOs) form in territorialized niches of peripheral tissues characterized by the presence of antigens; however, little is known about mechanism(s) of antigen handling by ectopic lymphoid structures. In this mini review, we will discuss the role of antigen-presenting cells and mechanisms of antigen presentation in TLOs, summarizing what is currently known about this facet of the formation and function of these tissues as well as identifying questions yet to be addressed.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Maffia, Dr Pasquale and Hughes, Dr Catherine and Benson, Dr Robert
Authors: Hughes, C. E., Benson, R. A., Bedaj, M., and Maffia, P.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Frontiers in Immunology
Publisher:Frontiers Media
ISSN:1664-3224
ISSN (Online):1664-3224
Copyright Holders:Copyright © 2016 Hughes, Benson, Bedaj and Maffia
First Published:First published in Frontiers in Immunology 7: 481
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
404921Investigating the role of T cells in vascular pathologyPaul GarsideBritish Heart Foundation (BHF)PG/06/083/21198III -IMMUNOLOGY
614711Defining innate and adaptive immune functions of plasmacytoid dendritic cells in atherosclerosis.Pasquale MaffiaBritish Heart Foundation (BHF)PG/12/81/29897III -IMMUNOLOGY
617771BHF centre of excellenceRhian TouyzBritish Heart Foundation (BHF)RE/13/5/30177RI CARDIOVASCULAR & MEDICAL SCIENCES
682541NanoMATePasquale MaffiaEuropean Commission (EC)661369III -IMMUNOLOGY
602451Rheumatoid Arthritis Centre of Excellence (RACE - Towards a Cure)Iain McInnesArthritis Research UK (ARUK)MP20298III -IMMUNOLOGY