Associations between single and multiple cardiometabolic diseases and cognitive abilities in 474 129 UK Biobank participants

Lyall, D. M. , Celis-Morales, C. A. , Anderson, J. , Gill, J. M.R. , Mackay, D. F. , McIntosh, A. M., Smith, D. J. , Deary, I. J., Sattar, N. and Pell, J. P. (2017) Associations between single and multiple cardiometabolic diseases and cognitive abilities in 474 129 UK Biobank participants. European Heart Journal, 38(8), pp. 577-583. (doi:10.1093/eurheartj/ehw528) (PMID:28363219)

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Abstract

Aims: Cardiometabolic diseases (hypertension, coronary artery disease [CAD] and diabetes are known to associate with poorer cognitive ability but there are limited data on whether having more than one of these conditions is associated with additive effects. We aimed to quantify the magnitude of their associations with non-demented cognitive abilities and determine the extent to which these associations were additive. Methods and results: We examined cognitive test scores in domains of reasoning, information processing speed and memory, included as part of the baseline UK Biobank cohort assessment (N = 474 129 with relevant data), adjusting for a range of potentially confounding variables. The presence of hypertension, CAD and diabetes generally associated with poorer cognitive scores on all tests, compared with a control group that reported none of these diseases. There was evidence of an additive deleterious dose effect of an increasing number of cardiometabolic diseases, for reasoning scores (unstandardized additive dose beta per disease = −0.052 score points out of 13, 95% CI [confidence intervals] −0.063 to − 0.041, P < 0.001), log reaction time scores (exponentiated beta = 1.005, i.e. 0.5% slower, 95% CI 1.004–1.005, P < 0.001) and log memory errors (exponentiated beta = 1.005 i.e. 0.5% more errors; 95% CI 1.003–1.008). Conclusion: Cardiometabolic diseases are associated with worse cognitive abilities, and the potential effect of an increasing number of cardiometabolic conditions appears additive. These results reinforce the notion that preventing or delaying cardiovascular disease or diabetes may delay cognitive decline and possible dementia.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Celis, Dr Carlos and Gill, Professor Jason and Smith, Professor Daniel and Anderson, Dr Jana and Pell, Professor Jill and Mackay, Dr Daniel and Sattar, Professor Naveed and Lyall, Dr Donald
Authors: Lyall, D. M., Celis-Morales, C. A., Anderson, J., Gill, J. M.R., Mackay, D. F., McIntosh, A. M., Smith, D. J., Deary, I. J., Sattar, N., and Pell, J. P.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > Public Health
Journal Name:European Heart Journal
Publisher:Oxford University Press
ISSN:0195-668X
ISSN (Online):1522-9645
Published Online:16 November 2016
Copyright Holders:Copyright © 2016 The Authors
First Published:First published in European Heart Journal 38(8): 577-583
Publisher Policy:Reproduced under a Creative Commons License

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