Calculation of airborne cleanliness and air supply rate for non-unidirectional airflow cleanrooms

Whyte, W. , Lenegan, N. and Eaton, T. (2016) Calculation of airborne cleanliness and air supply rate for non-unidirectional airflow cleanrooms. European Journal of Parenteral and Pharmaceutical Sciences, 21(3), pp. 79-88.

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Equations have been recently derived by Whyte, Lenegan and Eaton for calculating the airborne concentration of particles and microbe-carrying particles in non-unidirectional airflow cleanrooms. These equations cover a variety of ventilation systems, and contain the variables of air supply rate, airborne dispersion rate of contamination from machinery and people, surface deposition of particles from the air, concentration of contamination in fresh make-up air, proportion of fresh air, and air filter efficiencies. The relative importance of these variables is investigated in this present research paper, with particular regard to the removal efficiency, location, and number of air filters. It was shown that air filters were important in ensuring low levels of contamination in cleanrooms but the types of filters specified in current cleanroom designs were very effective in ensuring a minimal contribution to the cleanroom’s airborne contamination especially when a secondary filter is used in addition to a primary and terminal filter. The most important determinants of airborne contamination were the air supply rate and the dispersion rate of contamination within the cleanroom, with a lesser effect from deposition of airborne particles onto cleanroom surfaces. The information gathered confirmed the usefulness of the equation previously used by Whyte, Whyte, Eaton and Lenegan to calculate the air supply rate required for a specified concentration of airborne contamination.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Whyte, Dr William
Authors: Whyte, W., Lenegan, N., and Eaton, T.
College/School:College of Science and Engineering > School of Engineering
Journal Name:European Journal of Parenteral and Pharmaceutical Sciences
Publisher:Euromed Communications
Copyright Holders:Copyright © 2016 Pharmaceutical and Healthcare Sciences Society
First Published:First published in European Journal of Parenteral and Pharmaceutical Sciences 21(3):79-88
Publisher Policy:Reproduced with the permission of the publisher.

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