The Greenland shark: A new challenge for the oxidative stress theory of ageing?

Costantini, D., Smith, S., Killen, S. S. , Nielsen, J. and Steffensen, J. F. (2017) The Greenland shark: A new challenge for the oxidative stress theory of ageing? Comparative Biochemistry and Physiology. Part A: Molecular and Integrative Physiology, 203, pp. 227-232. (doi:10.1016/j.cbpa.2016.09.026) (PMID:27717642)

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Abstract

The free radical theory of ageing predicts that long-lived species should be more resistant to oxidative damage than short-lived species. Although many studies support this theory, recent studies found notable exceptions that challenge the generality of this theory. In this study, we have analysed the oxidative status of the Greenland shark (Somniosus microcephalus), which has recently been found as the longest living vertebrate animal known to science with a lifespan of at least 272 years. As compared to other species, the Greenland shark had body mass-corrected values of muscle glutathione peroxidase and red blood cells protein carbonyls (metric of protein oxidative damage) above 75 percentile and below 25 percentile, respectively. None of the biochemical metrics of oxidative status measured in either skeletal muscle or red blood cells were correlated with maximum lifespan of species. We propose that the values of metrics of oxidative status we measured might be linked to ecological features (e.g., adaptation to cold waters and deep dives) of this shark species rather to its lifespan.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Costantini, Dr David and Killen, Dr Shaun
Authors: Costantini, D., Smith, S., Killen, S. S., Nielsen, J., and Steffensen, J. F.
College/School:College of Medical Veterinary and Life Sciences > Institute of Biodiversity Animal Health and Comparative Medicine
Journal Name:Comparative Biochemistry and Physiology. Part A: Molecular and Integrative Physiology
Publisher:Elsevier
ISSN:1095-6433
ISSN (Online):1531-4332
Published Online:04 October 2016
Copyright Holders:Copyright © 2016 Elsevier Inc.
First Published:First published in Comparative Biochemistry and Physiology. Part A: Molecular and Integrative Physiology 203: 227-232
Publisher Policy:Reproduced in accordance with the publisher copyright policy

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