Weight losses with low energy formula diets in obese patients with and without type 2 diabetes: Systematic review and meta-analysis

Leslie, W.S., Taylor, R., Harris, L. and Lean, M.E.J. (2017) Weight losses with low energy formula diets in obese patients with and without type 2 diabetes: Systematic review and meta-analysis. International Journal of Obesity, 41(1), pp. 96-101. (doi:10.1038/ijo.2016.175) (PMID:27698345)

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Abstract

Aim: To provide a systematic review, of published data, to compare weight losses following very low calorie (<800 kcal per day VLCD) or low-energy liquid-formula (>800 kcal per day LELD) diets, in people with and without type 2 diabetes mellitus (T2DM). Methods: Systematic electronic searches of Medline (1946–2015) and Embase (1947–2015) to identify published studies using formula total diet replacement diets (VLCD/LELD). Random effects meta-analysis using weighted mean difference (WMD) in body weight between groups (with and without diabetes) as the summary estimate. Results: Final weight loss, in the five included studies, weighted for study sizes, (n=569, mean BMI=35.5–42.6 kg/m2), was not significantly different between participants with and without T2DM: −1.2 kg; 95% CI: −4.1 to 1.6 kg). Rates of weight loss were also similar in the two groups −0.6 kg per week (T2DM) and 0.5 kg per week (no diabetes), and for VLCD (lt;800 kcal per day) and LELD (>800 kcal per day). Conclusions: Weight losses with liquid-formula diets are very similar for VLCD and LELD and for obese subjects with or without T2DM. They can potentially achieve new weight loss/ maintenance targets of >15–20% for people with severe and medically complicated obesity.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Lean, Professor Michael and Harris, Dr Leanne and Leslie, Dr Wilma
Authors: Leslie, W.S., Taylor, R., Harris, L., and Lean, M.E.J.
College/School:College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > Mental Health and Wellbeing
College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
Journal Name:International Journal of Obesity
Publisher:Nature Publishing Group
ISSN:0307-0565
ISSN (Online):1476-5497
Published Online:04 October 2016
Copyright Holders:Copyright © 2017 Macmillan Publishers Limited, part of Springer Nature
First Published:First published in International Journal of Obesity 41(1): 96-101
Publisher Policy:Reproduced in accordance with the publisher copyright policy

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