Sex-differences in the effect of fish oil supplementation on the adaptive response to resistance exercise training in older people: a randomized control trial

Da Boit, M., Sibson, R., Meakin, J. R., Aspden, R. M., Thies, F., Mangoni, A. A. and Gray, S. R. (2016) Sex-differences in the effect of fish oil supplementation on the adaptive response to resistance exercise training in older people: a randomized control trial. American Journal of Clinical Nutrition, 4(12), e12834. (doi:10.14814/phy2.12834) (PMID:27354538) (PMCID:PMC4923234)

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Abstract

Resistance exercise training is known to be effective in increasing muscle mass in older people. Acute measurement of protein metabolism data has indicated that the magnitude of response may differ between sexes. We compared adaptive responses in muscle mass and function to 18 weeks resistance exercise training in a cohort of older (>65 years) men and women. Resistance exercise training improved knee extensor maximal torque, 4 m walk time, time to complete five chair rises, muscle anatomical cross‐sectional area (ACSA) and muscle quality with no effect on muscle fat/water ratio or plasma glucose, insulin, triacylglycerol, IL‐6, and TNF‐α. Differences between sexes were observed for knee extensor maximal torque and muscle quality with greater increases observed in men versus women (P < 0.05). Maximal torque increased by 15.8 ± 10.6% in women and 41.7 ± 25.5% in men, whereas muscle quality increased by 8.8 ± 17.5% in women and by 33.7 ± 25.6% in men. In conclusion, this study has demonstrated a difference in the magnitude of adaptation, of some of the outcome measures employed, in response to 18 weeks of resistance exercise training between men and women. The mechanisms underlying this observation remain to be established.

Item Type:Articles
Additional Information:This work was supported by the Biotechnology and Biological Sciences Research Council (BB/J015911/1).
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Gray, Dr Stuart
Authors: Da Boit, M., Sibson, R., Meakin, J. R., Aspden, R. M., Thies, F., Mangoni, A. A., and Gray, S. R.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
Journal Name:American Journal of Clinical Nutrition
Publisher:American Society for Nutrition
ISSN:0002-9165
ISSN (Online):1938-3207
Published Online:28 June 2016
Copyright Holders:Copyright © 2016 The Authors
First Published:First published in American Journal of Clinical Nutrition 4(12):e12834
Publisher Policy:Reproduced under a Creative Commons License

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