Interventions for age-related diseases: Shifting the paradigm

Figueira, I. et al. (2016) Interventions for age-related diseases: Shifting the paradigm. Mechanisms of Ageing and Development, 160, pp. 69-92. (doi: 10.1016/j.mad.2016.09.009)

Abstract

Over 60% of people aged over 65 are affected by multiple morbidities, which are more difficult to treat, generate increased healthcare costs and lead to poor quality of life compared to individual diseases. With the number of older people steadily increasing this presents a societal challenge. Age is the major risk factor for age-related diseases and recent research developments have led to the proposal that pharmacological interventions targeting common mechanisms of ageing may be able to delay the onset of multimorbidity. Here we review the state of the knowledge of multimorbidity, appraise the available evidence supporting the role of mechanisms of ageing in the development of the most common age-related diseases and assess potential molecules that may successfully target those key mechanisms.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Selman, Professor Colin
• Authors: Figueira, I., Fernandes, A., Mladenovic, A., Lopez-Contreras, A., Henriques, C. M., Selman, C., Ferreiro, E., Gonos, E. S., Trejo, J. L., Misra, J., Rasmussen, L. J., Xapelli, S., Ellam, T., and Bellantuono, I.
• College/School: College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine
• Journal Name: Mechanisms of Ageing and Development
• Publisher: Elsevier
• ISSN: 0047-6374
• ISSN (Online): 1872-6216
• Published Online: 29 September 2016
• Copyright Holders: Copyright © 2016 The Authors
• First Published: First published in Mechanisms of Ageing and Development 160:69-92
• Publisher Policy: Reproduced under a Creative Commons License