Complex polarity: building multicellular tissues through apical membrane traffic

Roman-Fernandez, A. and Bryant, D. M. (2016) Complex polarity: building multicellular tissues through apical membrane traffic. Traffic, 17(12), pp. 1244-1261. (doi: 10.1111/tra.12417) (PMID:27281121)

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The formation of distinct subdomains of the cell surface is crucial for multicellular organism development. The most striking example of this is apical-basal polarization. What is much less appreciated is that underpinning an asymmetric cell surface is an equally dramatic intracellular endosome rearrangement. Here, we review the interplay between classical cell polarity proteins and membrane trafficking pathways, and discuss how this marriage gives rise to cell polarization. We focus on those mechanisms that regulate apical polarization, as this is providing a number of insights into how membrane traffic and polarity are regulated at the tissue level.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Roman Fernandez, Mr Alvaro and Bryant, Dr David
Authors: Roman-Fernandez, A., and Bryant, D. M.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
Journal Name:Traffic
ISSN (Online):1600-0854
Published Online:01 July 2016
Copyright Holders:Copyright © 2016 John Wiley and Sons.
First Published:First published in Traffice 17(12):1244-1261
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

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