Palladium-catalysed heterocyclisation: a carbon-centred approach

Phillips, D. and France, D. J. (2017) Palladium-catalysed heterocyclisation: a carbon-centred approach. Asian Journal of Organic Chemistry, 6(1), pp. 27-40. (doi:10.1002/ajoc.201600410)

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Abstract

Heterocycles are some of the most important and widely used motifs in synthetic and medicinal chemistry. It is therefore not surprising that the synthesis of heterocycles is a rich area of chemistry. Catalytic heterocyclisation that makes use of heteroatom nucleophiles such as oxygen and nitrogen is one such powerful strategy. This Focus Review considers an alternative approach using carbon-based nucleophiles generated during palladium-catalysed heterocyclisation. This complimentary method allows access to a range of useful and otherwise inaccessible targets. Occurring through a range of different mechanisms, the utility of this approach can be seen in the wide range of transformations that can be undertaken, along with its repeated application in complex molecule synthesis.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:France, Dr David and Phillips, Mr David
Authors: Phillips, D., and France, D. J.
College/School:College of Science and Engineering > School of Chemistry
Journal Name:Asian Journal of Organic Chemistry
Publisher:Wiley
ISSN:2193-5815
ISSN (Online):2193-5815
Published Online:11 October 2016

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
608951Engineering and Physical Sciences Doctoral Training Grant 2012-16Mary Beth KneafseyEngineering & Physical Sciences Research Council (EPSRC)EP/K503058/1VICE PRINCIPAL RESEARCH & ENTERPRISE