T cells, teeth and tissue destruction - what do T cells do in periodontal disease?

Campbell, L., Millhouse, E., Malcolm, J. and Culshaw, S. (2016) T cells, teeth and tissue destruction - what do T cells do in periodontal disease? Molecular Oral Microbiology, 31(6), pp. 445-456. (doi:10.1111/omi.12144) (PMID:26505640)

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Abstract

The microbial plaque biofilm resides adjacent to the tissue-destructive inflammatory infiltrate in periodontitis. Although not sufficient, this biofilm is necessary for this inflammatory response. Patients with periodontitis generate antibodies specific for bacteria in the biofilm – although the role of these antibodies is not clear, there is, undoubtedly, an adaptive immune response in periodontitis. T lymphocytes are central to adaptive immunity, and provide help for B cells to generate specific antibodies. T-cell receptor recognition of peptide antigen in the context of major histocompatibility complex can result in T-cell activation. The activation and differentiation of the T-cell can take many forms, and hence numerous types of T cells have been described. The role of adaptive immune responses, and the T-cell component thereof, in periodontitis remains relatively poorly defined. This review aims to broadly summarize findings about T cells and their role in periodontitis, focusing primarily on studies of human disease with a short discussion of some animal studies.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Malcolm, Dr Jennifer and Culshaw, Dr Shauna and Millhouse, Dr Emma
Authors: Campbell, L., Millhouse, E., Malcolm, J., and Culshaw, S.
College/School:College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing > Dental School
Journal Name:Molecular Oral Microbiology
Publisher:Wiley
ISSN:2041-1006
ISSN (Online):2041-1014
Published Online:27 October 2015

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
535611Gums and JointsShauna CulshawEuropean Commission (EC)261460SM - DENTAL SCHOOL
656691Investigating the immune response to citrullinated antigenShauna CulshawArthritis Research UK (ARUK)20823SM - DENTAL SCHOOL