Progress Towards a Multi-Modal Capsule Endoscopy Device Featuring Microultrasound Imaging

Lay, H.S. et al. (2016) Progress Towards a Multi-Modal Capsule Endoscopy Device Featuring Microultrasound Imaging. In: 2016 IEEE International Ultrasonics Symposium, Tours, France, 18-21 Sept 2016, ISBN 9781467398978 (doi:10.1109/ULTSYM.2016.7728692)

Lay, H.S. et al. (2016) Progress Towards a Multi-Modal Capsule Endoscopy Device Featuring Microultrasound Imaging. In: 2016 IEEE International Ultrasonics Symposium, Tours, France, 18-21 Sept 2016, ISBN 9781467398978 (doi:10.1109/ULTSYM.2016.7728692)

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Abstract

Current clinical standards for endoscopy in the gastrointestinal (GI) tract combine high definition optics and ultrasound imaging to view the lumen superficially and through its thickness. However, these instruments are limited to the length of an endoscope and the only clinically available, autonomous devices able to travel the full length of the GI tract easily offer only video capsule endoscopy (VCE). Our work seeks to overcome this limitation with a device (“Sonopill”) for multimodal capsule endoscopy, providing optical and microultrasound (μUS) imaging and supporting sensors1. μUS transducers have been developed with multiple piezoelectric materials operating across a range of centre frequencies to study viability in the GI tract. Because of the combined constraints of μUS imaging and the low power / heat tolerance of autonomous devices, a hybrid approach has been taken to the transducer design, with separate transmit and receive arrays allowing multiple manufacturing approaches to maximise system efficiency. To explore these approaches fully, prototype devices have been developed with PVDF, high-frequency PZT and PMN-PT composites, and piezoelectric micromachined ultrasonic transducer arrays. Test capsules have been developed using 3D printing to investigate issues including power consumption, heat generation / dissipation, acoustic coupling, signal strength and capsule integrity. Because of the high functional density of the electronics in our proposed system, application specific integrated circuits (ASICs) have been developed to realise the ultrasound transmit and receive circuitry along with white-light and autofluorescence imaging with single-photon avalanche detectors (SPADs). The ultrasound ASIC has been developed and the SPAD electronics and optical subsystem have been validated experimentally. The functionality of various transducer materials has been examined as a function of frequency and ultrasound transducers have been developed to operate at centre frequencies in the range 15 - 50 MHz. Ex vivo testing of porcine tissue has been performed, generating images of interest to the clinical community, demonstrating the viability of the Sonopill concept.

Item Type:Conference Proceedings
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Cochran, Professor Alexander and Al-Rawhani, Dr Mohammed and Lay, Dr Holly and Seetohul, Dr Vipin and Cumming, Professor David and Qiu, Dr Yongqiang and Beeley, Mr James and Demore, Dr Christine
Authors: Lay, H.S., Qiu, Y., Al-Rawhani, M., Beeley, J., Poltarjonoks, R., Seetohul, V., Cumming, D., Cochran, S., Cummins, G., Desmulliez, M.P.Y., Wallace, M., Trolier-McKinstry, S., McPhillips, R., Cox, B.F., and Demore, C.E.M.
College/School:College of Science and Engineering > School of Engineering > Electronics and Nanoscale Engineering
College of Science and Engineering > School of Engineering > Systems Power and Energy
ISSN:1948-5727
ISBN:9781467398978
Copyright Holders:Copyright © 2016 Institute of Electrical and Electronics Engineers
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
748241Sonopill: minimally invasive gastrointestinal diagnosis and therapyAlexander CochranEngineering & Physical Sciences Research Council (EPSRC)EP/K034537/2ENG - ENGINEERING SYSTEMS POWER & ENERGY
605821The Multi-Corder: Poly-Sensor TechnologyDavid CummingEngineering & Physical Sciences Research Council (EPSRC)EP/K021966/1ENG - ENGINEERING ELECTRONICS & NANO ENG