Mammalian autophagy degrades nuclear constituents in response to tumorigenic stress

Dou, Z., Ivanov, A., Adams, P. D. and Berger, S. L. (2016) Mammalian autophagy degrades nuclear constituents in response to tumorigenic stress. Autophagy, 12(8), pp. 1416-1417. (doi: 10.1080/15548627.2015.1127465) (PMID:26654219)

Abstract

During autophagy, double-membrane autophagosomes are observed in the cytoplasm. Thus, extensive studies have focused on autophagic turnover of cytoplasmic material. Whether autophagy has a role in degrading nuclear constituents is poorly understood. We reveal that the autophagy protein LC3/Atg8 directly interacts with the nuclear lamina protein LMNB1 (lamin B1), and binds to LMN/lamin-associated chromatin domains (LADs). Through these interactions, autophagy specifically mediates destruction of nuclear lamina during tumorigenic stress, such as by activated oncogenes and DNA damage. This nuclear lamina degradation upon aberrant cellular stress impairs cell proliferation by inducing cellular senescence, a stable form of cell-cycle arrest and a tumor-suppressive mechanism. Our findings thus suggest that, in response to cancer-promoting stress, autophagy degrades nuclear material to drive cellular senescence, as a means to restrain tumorigenesis. Our work provokes a new direction in studying the role of autophagy in the nucleus and in tumor suppression.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Adams, Professor Peter
• Authors: Dou, Z., Ivanov, A., Adams, P. D., and Berger, S. L.
• College/School: College of Medical Veterinary and Life Sciences > School of Cancer Sciences
• Journal Name: Autophagy
• Publisher: Taylor & Francis
• ISSN: 1554-8627
• ISSN (Online): 1554-8635
• Published Online: 10 December 2015
• Copyright Holders: Copyright © 2016 Taylor and Francis
• First Published: First published in Autophagy 12(8): 1416-1417
• Publisher Policy: Reproduced in accordance with the publisher copyright policy