Taxonomy of segmental myocardial systolic dysfunction

McDiarmid, A. K., Pellicori, P. , Cleland, J. G.F. and Plein, S. (2017) Taxonomy of segmental myocardial systolic dysfunction. European Heart Journal, 38(13), pp. 942-954. (doi: 10.1093/eurheartj/ehw140) (PMID:27147609) (PMCID:PMC5381597)

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The terms used to describe different states of myocardial health and disease are poorly defined. Imprecision and inconsistency in nomenclature can lead to difficulty in interpreting and applying trial outcomes to clinical practice. In particular, the terms ‘viable’ and ‘hibernating’ are commonly applied interchangeably and incorrectly to myocardium that exhibits chronic contractile dysfunction in patients with ischaemic heart disease. The range of inherent differences amongst imaging modalities used to define myocardial health and disease add further challenges to consistent definitions. The results of several large trials have led to renewed discussion about the classification of dysfunctional myocardial segments. This article aims to describe the diverse myocardial pathologies that may affect the myocardium in ischaemic heart disease and cardiomyopathy, and how they may be assessed with non-invasive imaging techniques in order to provide a taxonomy of myocardial dysfunction.

Item Type:Articles
Additional Information:A.K.M. is funded by a British Heart Foundation (BHF) Project Grant (PG/ 14/10/30641). S.P. is funded by a BHF Clinical Fellowship (FS/10/62/ 28409). Funding to pay the Open Access publication charges for this article was provided by The British Heart Foundation (BHF).
Glasgow Author(s) Enlighten ID:Cleland, Professor John and Pellicori, Dr Pierpaolo
Authors: McDiarmid, A. K., Pellicori, P., Cleland, J. G.F., and Plein, S.
Subjects:R Medicine > R Medicine (General)
College/School:College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > Robertson Centre
Journal Name:European Heart Journal
Publisher:Oxford University Press
ISSN (Online):1522-9645
Published Online:04 May 2016
Copyright Holders:Copyright © 2016 The Authors
First Published:First published in European Heart Journal 38(13):942-954
Publisher Policy:Reproduced under a Creative Commons License

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