Clinical correlates and prognostic value of proenkephalin in acute and chronic heart failure

Matsue, Y. et al. (2017) Clinical correlates and prognostic value of proenkephalin in acute and chronic heart failure. Journal of Cardiac Failure, 23(3), pp. 231-239. (doi: 10.1016/j.cardfail.2016.09.007) (PMID:27663098)

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Background: Proenkephalin (pro-ENK) has emerged as a novel biomarker associated with both renal function and cardiac function. However, its clinical and prognostic value have not been well evaluated in symptomatic patients with heart failure. Methods and Results: The association between pro-ENK and markers of renal function was evaluated in 95 patients with chronic heart failure who underwent renal hemodynamic measurements including renal blood flow (RBF) and glomerular filtration rate (GFR) using131I-Hippuran and 125I-Iothalamate clearances, respectively. The association between pro-ENK and clinical outcome in acute heart failure was assessed in another 1589 patients. Pro-ENK was strongly correlated with both RBF (P*lt;0.001) and GFR (P<0.001), but not with renal tubular markers. In the acute heart failure cohort, pro-ENK was a predictor of death through 180 days, heart failure rehospitalization through 60 days, and death or cardiovascular or renal rehospitalization through day 60 in univariable analyses, but its predictive value was lost in a multivariable model, when other renal markers were entered in the model. Conclusions: In patients with chronic and acute heart failure, pro-ENK is strongly associated with glomerular function, but not with tubular damage. Pro-ENK provides limited prognostic information in patients with acute heart failure on top of established renal markers.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Cleland, Professor John and Damman, Dr Kevin
Authors: Matsue, Y., ter Maaten, J. M., Struck, J., Metra, M., O'Connor, C. M., Ponikowski, P., Teerlink, J. R., Cotter, G., Davison, B., Cleland, J. G.F., Givertz, M. M., Bloomfield, D. M., Dittrich, H. C., van Veldhuisen, D. J., van der Meer, P., Damman, K., and Voors, A. A.
Subjects:R Medicine > R Medicine (General)
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > Robertson Centre
Journal Name:Journal of Cardiac Failure
ISSN (Online):1532-8414
Published Online:20 September 2016
Copyright Holders:Copyright © 2016 Elsevier Inc.
First Published:First published in Journal of Cardiac Failure 23(3):231-239
Publisher Policy:Reproduced in accordance with the publisher copyright policy

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