Programming of adiposity in childhood and adolescence: associations with birth weight and cord blood adipokines

Simpson, J., Smith, A. D.A.C., Fraser, A., Sattar, N. , Lindsay, R. S. , Ring, S. M., Tilling, K., Smith, G. D., Lawlor, D. A. and Nelson, S. M. (2017) Programming of adiposity in childhood and adolescence: associations with birth weight and cord blood adipokines. Journal of Clinical Endocrinology and Metabolism, 102(2), pp. 499-506. (doi:10.1210/jc.2016-2342) (PMID:27841944) (PMCID:PMC5413167)

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Abstract

Context: Exposure to maternal adiposity during pregnancy is associated with higher offspring birthweight and greater adiposity through childhood and adult life. As birthweight reflects the summation of lean and fat mass, the extent to which fat mass at birth tracks into later life is unknown. Objective: Determine whether fat mass at birth is associated with child and adolescent adiposity. Design, Setting and Participants: UK birth cohort with markers of neonatal fat mass; cord blood leptin, adiponectin, and birthweight and adiposity outcomes at age 9 (N=2775) and 17years (N=2138). Main Outcomes: Offspring BMI, waist circumference, DXA-determined fat mass and obesity at age 9 and 17years. Results: Higher cord blood leptin was associated with higher z-scores of fat mass (difference in mean per 10pg/ml: 0.03SD,95%CI 0.00-0.06), waist circumference (0.04SD,95%CI 0.00-0.07), and BMI (0.04SD,95%CI 0.00-0.08), at age 9. However, by age 17 the adjusted results were attenuated to the null. Cord blood adiponectin was not associated with measures of adiposity at age 9. At age 17, cord blood adiponectin was positively associated with fat mass (0.02SD per 10μg/ml,95%CI 0.02-0.03) and waist circumference (0.04SD per 10μg/ml,95%CI 0.03-0.05). Birthweight was positively associated with waist circumference (0.03SD per 100g,95%CI 0.02-0.04) and BMI (0.02SD per 100g,95%CI 0.00-0.03), but not fat mass or odds of obesity. Cord blood leptin and adiponectin were not associated with obesity at either age. Conclusions: Increased cord blood leptin and adiponectin, known surrogates of fetal fat mass, were weakly associated with increased fat mass in late childhood and adolescence respectively.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Lindsay, Dr Robert and Nelson, Professor Scott and Simpson, Dr Joy and Sattar, Professor Naveed
Authors: Simpson, J., Smith, A. D.A.C., Fraser, A., Sattar, N., Lindsay, R. S., Ring, S. M., Tilling, K., Smith, G. D., Lawlor, D. A., and Nelson, S. M.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
Journal Name:Journal of Clinical Endocrinology and Metabolism
Publisher:Endocrine Society
ISSN:0021-972X
ISSN (Online):1945-7197
Published Online:14 November 2016
Copyright Holders:Copyright © 2016 The Authors
First Published:First published in Journal of Clinical Endocrinology and Metabolism 102(2):499-506
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
557181Do measures in cord blood predict long term offspring phenotype?Scott NelsonWellcome Trust (WELLCOME)094311/Z/10/ZMVLS MED - REPRODUCTIVE & MATERNAL MED