Interleukin-33 in health and disease

Liew, F. Y., Girard, J.-P. and Turnquist, H. R. (2016) Interleukin-33 in health and disease. Nature Reviews Immunology, 16(11), pp. 676-689. (doi: 10.1038/nri.2016.95) (PMID:27640624)

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Interleukin-33 (IL-33) — a member of the IL-1 family — was originally described as an inducer of type 2 immune responses, activating T helper 2 (TH2) cells and mast cells. Now, evidence is accumulating that IL-33 also potently stimulates group 2 innate lymphoid cells (ILC2s), regulatory T (Treg) cells, TH1 cells, CD8+ T cells and natural killer (NK) cells. This pleiotropic nature is reflected in the role of IL-33 in tissue and metabolic homeostasis, infection, inflammation, cancer and diseases of the central nervous system. In this Review, we highlight the molecular and cellular characteristics of IL-33, together with its major role in health and disease and the potential therapeutic implications of these findings in humans.

Item Type:Articles
Additional Information:F.Y.L is supported by the Wellcome Trust and the Medical Research Council, UK. J.-P.G. is supported by grants from Agence Nationale de la Recherche (ANR‑12‑BSV3‑0005‑01), Institut National du Cancer (INCA) and Fondation ARC. H.R.T. is supported by grants from the US National Institutes of Health, National Heart, Lung, and Blood Institutes (R01 HL122489) and the National Institute of Allergy and Infectious Diseases (R21 AI121981).
Glasgow Author(s) Enlighten ID:Liew, Prof Foo
Authors: Liew, F. Y., Girard, J.-P., and Turnquist, H. R.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Nature Reviews Immunology
Publisher:Nature Publishing Group
ISSN (Online):1474-1741
Published Online:19 September 2016

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