The androgen receptor gene CAG repeat in relation to 4-year changes in androgen-sensitive endpoints in community-dwelling older European men

Eendebak, R. J.A.H. et al. (2016) The androgen receptor gene CAG repeat in relation to 4-year changes in androgen-sensitive endpoints in community-dwelling older European men. European Journal of Endocrinology, 175(6), pp. 583-593. (doi: 10.1530/EJE-16-0447) (PMID:27634944)

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Context: The androgen receptor (AR) gene exon 1 CAG repeat length has been proposed to be a determinant of between-individual variations in androgen action in target tissues, which might regulate phenotypic differences of human ageing. However, findings on its phenotypic effects are inconclusive. Objective: To assess whether the AR CAG repeat length is associated with longitudinal changes in endpoints that are influenced by testosterone (T) levels in middle-aged and elderly European men. Design: Multinational European observational prospective cohort study. Participants: A total of 1887 men (mean ± S.D. age: 63 ± 11 years; median follow up: 4.3 years) from centres of eight European countries comprised the analysis sample after exclusion of those with diagnosed diseases of the hypothalamic–pituitary–testicular (HPT) axis. Main outcome measures: Longitudinal associations between the AR CAG repeat and changes in androgen-sensitive endpoints (ASEs) and medical conditions were assessed using regression analysis adjusting for age and centre. The AR CAG repeat length was treated as both a continuous and a categorical (6–20; 21–23; 24–39 repeats) predictor. Additional analysis investigated whether results were independent of baseline T or oestradiol (E2) levels. Results: The AR CAG repeat, when used as a continuous or a categorical predictor, was not associated with longitudinal changes in ASEs or medical conditions after adjustments. These results were independent of T and E2 levels. Conclusion: Within a 4-year time frame, variations in the AR CAG repeat do not contribute to the rate of phenotypic ageing, over and above, which might be associated with the age-related decline in T levels.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Lean, Professor Michael
Authors: Eendebak, R. J.A.H., Huhtaniemi, I., Pye, S. R., Ahern, T. B., O'Neill, T. W., Bartfai, G., Casanueva, F. F., Maggi, M., Forti, G., Alston, R. D., Giwercman, A., Han, T. S., Kula, K., Lean, M. E.J., Punab, M., Pendleton, N., Keevil, B., Vanderschueren, D., Rutter, M. K., Tampubolon, G., Goodacre, R., and Wu, F. C.W.
College/School:College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
Journal Name:European Journal of Endocrinology
ISSN (Online):1479-683X
Published Online:15 September 2016

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