Rôle of contrast media viscosity in altering vessel wall shear stress and relation to the risk of contrast extravasations

Sakellariou, S., Li, W., Paul, M. C. and Roditi, G. (2016) Rôle of contrast media viscosity in altering vessel wall shear stress and relation to the risk of contrast extravasations. Medical Engineering and Physics, 38(12), pp. 1426-1433. (doi: 10.1016/j.medengphy.2016.09.016) (PMID:27729199)

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Iodinated contrast media (CM) are the most commonly used injectables in radiology today. A range of different media are commercially available, combining various physical and chemical characteristics (ionic state, osmolality, viscosity) and thus exhibiting distinct in vivo behaviour and safety profiles. In this paper, numerical simulations of blood flow with contrast media were conducted to investigate the effects of contrast viscosity on generated vessel wall shear stress and vessel wall pressure to elucidate any possible relation to extravasations. Five different types of contrast for Iodine fluxes ranging at 1.5–2.2 gI/s were modelled through 18 G and 20 G cannulae placed in an ideal vein at two different orientation angles. Results demonstrate that the least viscous contrast media generate the least maximum wall shear stress as well as the lowest total pressure for the same flow rate. This supports the empirical clinical observations and hypothesis that more viscous contrast media are responsible for a higher percentage of contrast extravasations. In addition, results support the clinical hypothesis that a catheter tip directed obliquely to the vein wall always produces the highest maximum wall shear stress and total pressure due to impingement of the contrast jet on the vessel wall.

Item Type:Articles
Keywords:Contrast media, blood flow, numerical modelling, wall shear stress, extravasation.
Glasgow Author(s) Enlighten ID:Li, Dr Wenguang and Paul, Professor Manosh and Roditi, Dr Giles
Authors: Sakellariou, S., Li, W., Paul, M. C., and Roditi, G.
College/School:College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
College of Science and Engineering > School of Engineering > Biomedical Engineering
Journal Name:Medical Engineering and Physics
Publisher:Elsevier Science
ISSN (Online):1873-4030
Published Online:08 October 2016
Copyright Holders:Copyright © 2016 Elsevier
First Published:First published in Medical Engineering and Physics 38(12):1426-1433
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

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