The discovery and SAR of indoline-3-carboxamides—A new series of 5-HT6 antagonists

Reid, M. et al. (2010) The discovery and SAR of indoline-3-carboxamides—A new series of 5-HT6 antagonists. Bioorganic and Medicinal Chemistry Letters, 20(12), pp. 3713-3716. (doi:10.1016/j.bmcl.2010.04.085)

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Abstract

Antagonists of the 5-HT6 receptor have been shown to improve cognitive function in a wide range of animal models and as such may prove to be attractive agents for the symptomatic treatment of cognitive disorders such as Alzheimer’s disease (AD) and schizophrenia. We report herein the identification and SAR around N-(2-aminoalkyl)-1-(arylsulfonyl)indoline-3-carboxamides—a novel chemotype of 5-HT6 antagonists.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Thomson, Dr Fiona
Authors: Reid, M., Carlyle, I., Caulfield, W. L., Clarkson, T. R., Cusick, F., Epemolu, O., Gilfillan, R., Goodwin, R., Jaap, D., O’Donnell, E. C., Presland, J., Rankovic, Z., Spinks, D., Spinks, G., Thomson, A. M., Thomson, F., Strain, J., and Wishart, G.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
Journal Name:Bioorganic and Medicinal Chemistry Letters
Publisher:Elsevier
ISSN:0960-894X
Published Online:24 April 2010

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