The discovery and SAR of indoline-3-carboxamides—A new series of 5-HT6 antagonists

Reid, M. et al. (2010) The discovery and SAR of indoline-3-carboxamides—A new series of 5-HT6 antagonists. Bioorganic and Medicinal Chemistry Letters, 20(12), pp. 3713-3716. (doi: 10.1016/j.bmcl.2010.04.085)

Abstract

Antagonists of the 5-HT6 receptor have been shown to improve cognitive function in a wide range of animal models and as such may prove to be attractive agents for the symptomatic treatment of cognitive disorders such as Alzheimer’s disease (AD) and schizophrenia. We report herein the identification and SAR around N-(2-aminoalkyl)-1-(arylsulfonyl)indoline-3-carboxamides—a novel chemotype of 5-HT6 antagonists.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Thomson, Dr Fiona
• Authors: Reid, M., Carlyle, I., Caulfield, W. L., Clarkson, T. R., Cusick, F., Epemolu, O., Gilfillan, R., Goodwin, R., Jaap, D., O’Donnell, E. C., Presland, J., Rankovic, Z., Spinks, D., Spinks, G., Thomson, A. M., Thomson, F., Strain, J., and Wishart, G.
• College/School: College of Medical Veterinary and Life Sciences > School of Cancer Sciences
• Journal Name: Bioorganic and Medicinal Chemistry Letters
• Publisher: Elsevier
• ISSN: 0960-894X
• Published Online: 24 April 2010