The discovery of novel 8-azabicyclo[3.2.1]octan-3-yl)-3-(4-chlorophenyl) propanamides as vasopressin V1A receptor antagonists

Napier, S. et al. (2011) The discovery of novel 8-azabicyclo[3.2.1]octan-3-yl)-3-(4-chlorophenyl) propanamides as vasopressin V1A receptor antagonists. Bioorganic and Medicinal Chemistry Letters, 21(10), pp. 3163-3167. (doi:10.1016/j.bmcl.2011.02.096)

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Abstract

The discovery of a novel series of 8-azabicyclo[3.2.1]octan-3-yl)-3-(4-chlorophenyl) propanamide antagonists of the vasopressin V1A receptor is disclosed. Compounds 47 and 48 were found to be high affinity, selective vasopressin V1A antagonists.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Thomson, Dr Fiona
Authors: Napier, S., Wishart, G., Arbuckle, W., Baker, J., Barn, D., Bingham, M., Brown, A., Byford, A., Claxton, C., Craighead, M., Buchanan, K., Fielding, L., Gibson, L., Goodwin, R., Goutcher, S., Irving, N., MacSweeney, C., Milne, R., Mort, C., Presland, J., Sloan, H., Thomson, F., Turnbull, Z., and Young, T.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
Journal Name:Bioorganic and Medicinal Chemistry Letters
Publisher:Elsevier
ISSN:0960-894X
Published Online:04 March 2011

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