Exploiting the Achilles' heel of membrane trafficking in trypanosomes

Zoltner, M., Horn, D., de Koning, H. P. and Field, M. C. (2016) Exploiting the Achilles' heel of membrane trafficking in trypanosomes. Current Opinion in Microbiology, 34, pp. 97-103. (doi:10.1016/j.mib.2016.08.005) (PMID:27614711) (PMCID:PMC5176092)

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Abstract

Pathogenic protozoa are evolutionarily highly divergent from their metazoan hosts, reflected in many aspects of their biology. One particularly important parasite taxon is the trypanosomatids. Multiple transmission modes, distinct life cycles and exploitation of many host species attests to great prowess as parasites, and adaptability for efficient, chronic infection. Genome sequencing has begun uncovering how trypanosomatids are well suited to parasitism, and recent genetic screening and cell biology are revealing new aspects of how to control these organisms and prevent disease. Importantly, several lines of evidence suggest that membrane transport processes are central for the sensitivity towards several frontline drugs.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:De Koning, Professor Harry
Authors: Zoltner, M., Horn, D., de Koning, H. P., and Field, M. C.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Current Opinion in Microbiology
Publisher:Elsevier
ISSN:1369-5274
ISSN (Online):1879-0364
Published Online:09 September 2016
Copyright Holders:Copyright © 2016 The Authors
First Published:First published in Current Opinion in Microbiology 34:97-103
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
639311Modes of Action and Mechanisms of Resistance to the Novel Benzoxaborole Class of Drug against Human African TrypanosomiasisMichael BarrettMedical Research Council (MRC)MR/L018853/1III - PARASITOLOGY