Multi-scale modelling of the human left ventricle

Cai, L., Gao, H. , Luo, X. and Nie, Y. (2015) Multi-scale modelling of the human left ventricle. Scientia Sinica Physica, Mechanica and Astronomica, 45(2), 24702. (doi:10.1360/SSPMA2013-00100)

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Abstract

In this paper, a multi-scale computational frame is proposed to simulate dynamics of the human left ventricle. First of all, a modified Level Set method is used to segment the cardiac magnetic resonance imaging and then reconstruct the 3D computational domain of the left ventricle. The Holzapfel-Ogden's nonlinear and anisotropic model is imposed to calculate the passive elastic response. The Fenton-Karma model with stimulus current is optimized to produce the reasonable membrane potential and intracellular calcium concentration. Based on the obtained calcium concentration, the active tension is calculated. Finally, the passive elastic response and the active tension of the left ventricle are coupled with the blood and the obtained fluid structure interaction is solved by the immersed boundary method. Our numerical results at end-diastole and end-systole are generally in good agreement with the clinical measurement and the earlier studies, which verifies the efficiency of the method.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Luo, Professor Xiaoyu and Gao, Dr Hao
Authors: Cai, L., Gao, H., Luo, X., and Nie, Y.
College/School:College of Science and Engineering > School of Mathematics and Statistics > Mathematics
Journal Name:Scientia Sinica Physica, Mechanica and Astronomica
Publisher:Science China Press
ISSN:1672-1780
Copyright Holders:Copyright © 2015 Science China Press
First Published:First published in Scientia Sinica Physica, Mechanica and Astronomica 45(2):24702
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

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