F-18 FDG PET-CT influences target delineation when combined with standard CT-based radiotherapy planning in the palliative setting in malignant pleural mesothelioma; an exploratory study

Mac Leod, N. et al. (2015) F-18 FDG PET-CT influences target delineation when combined with standard CT-based radiotherapy planning in the palliative setting in malignant pleural mesothelioma; an exploratory study. Reports of Radiotherapy and Oncology, 2(2), e3999. (doi: 10.17795/rro-3999)

[img]
Preview
Text
128681.pdf - Published Version
Available under License Creative Commons Attribution Non-commercial No Derivatives.

520kB

Abstract

Background: Positron emission tomography computerized tomography (PET-CT) is useful in radiotherapy planning for lung cancer. However, its role in malignant pleural mesothelioma (MPM) is unknown. Objectives: This exploratory study investigated the possible role for PET-CT in radiotherapy planning for MPM. Patients and Methods: Patients receiving radiotherapy for the treatment of pain in MPM, had fluorodeoxyglucose (FDG) PET-CT scanning in addition to their standard CT scan. PET-CT images were then fused with CT planning images, termed Planning-PET-CT. Target volume delineation was undertaken first using CT and subsequently incorporated Planning-PET-CT. Planning treatment volume (PTV), conformity index (CI), mean distance to conformity (MDC), center of gravity distance (CGD) and standard uptake values (SUV) were examined. Results: Sixteen patients were recruited into the study. PET-CT upstaged nine patients. No association between SUV max and either survival or pain response was seen. Volumes contoured using Planning-PET-CT differed markedly from those outlined using CT alone as shown by the following parameters: CI = 0.3 (0.24 - 0.38). MDC = 21.47 (16.73 - 33.70) and CGD = 16.40 (11.80 - 33.87). The median percentage of over contouring was 44.00% (34.33 - 72.50) with 46.67% under contoured (34.00 - 55.00). Conclusions: PET-CT alters the position of the PTV in MPM and upstaged a proportion of patients. Further work to elucidate the role of Planning-PET-CT in target volume definition is justified.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Findlay, Dr Caroline and Chalmers, Professor Anthony and Kelly, Mrs Caroline and Stobo, Mr Jon and Han, Dr Sai
Authors: Mac Leod, N., Stobo, J., O’Rourke, N., Hicks, J., Moore, K., Sankaralingam, M., Oommen, K., Kelly, C., McMahon, L., Poon, F. W., Han, S., Findlay, C., Chalmers, A., Fallon, M., and Laird, B. J.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
Journal Name:Reports of Radiotherapy and Oncology
Publisher:Shahid Beheshti University of Medical Sciences
ISSN:2345-3192
ISSN (Online):2345-3184
Published Online:12 June 2015
Copyright Holders:Copyright © 2015 Iranian Society of Clinical Oncology
First Published:First published in Reports of Radiotherapy and Oncology 2(2):e3999
Publisher Policy:Reproduced under a Creative Commons License

University Staff: Request a correction | Enlighten Editors: Update this record