Jackson-Jones, L. H. et al. (2016) IL-33 delivery induces serous cavity macrophage proliferation independent of interleukin-4 receptor alpha. European Journal of Immunology, 46(10), pp. 2311-2321. (doi: 10.1002/eji.201646442) (PMID:27592711)
|
Text
128622.pdf - Published Version Available under License Creative Commons Attribution. 1MB |
Abstract
IL-33 plays an important role in the initiation of type-2 immune responses, as well as the enhancement of type 2 effector functions. Engagement of the IL-33 receptor on macrophages facilitates polarization to an alternative activation state by amplifying IL-4 and IL-13 signaling to IL-4Rα. IL-4 and IL-13 also induce macrophage proliferation but IL-33 involvement in this process has not been rigorously evaluated. As expected, in vivo delivery of IL-33 induced IL-4Rα-dependent alternative macrophage activation in the serous cavities. IL-33 delivery also induced macrophages to proliferate but, unexpectedly, this was independent of IL-4Rα signaling. In a filarial nematode infection model in which IL-4Rα-dependent alternative activation and proliferation in the pleural cavity is well described, IL-33R was essential for alternative activation but not macrophage proliferation. Similarly, during Alternaria alternata induced airway inflammation, which provokes strong IL-33 responses, we observed that both IL-4Rα and IL-33R were required for alternative activation, while macrophage proliferation in the pleural cavity was still evident in the absence of either receptor alone. Our data show that IL-33R and IL-4Rα promote macrophage proliferation independently of each other, but both are essential for induction of alternative activation.
Item Type: | Articles |
---|---|
Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Maizels, Professor Rick |
Authors: | Jackson-Jones, L. H., Rückerl, D., Svedberg, F., Duncan, S., Maizels, R. M., Sutherland, T. E., Jenkins, S. J., McSorley, H. J., Bénézech, C., MacDonald, A. S., and Allen, J. E. |
Subjects: | ?? Alternaria ?? ?? IL-33 ?? ?? IL-4 ?? ?? Macrophage ?? ?? Nematode ?? ?? Proliferation ?? |
College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
Journal Name: | European Journal of Immunology |
Publisher: | Wiley |
ISSN: | 0014-2980 |
ISSN (Online): | 1521-4141 |
Published Online: | 05 September 2016 |
Copyright Holders: | Copyright © 2016 The Authors |
First Published: | First published in European Journal of Immunology 46(10);2311-2321 |
Publisher Policy: | Reproduced under a Creative Commons License |
University Staff: Request a correction | Enlighten Editors: Update this record